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Introduction
Although the term “targeted therapies” is now very trendy, for many years radiation oncologists and biologists have been attempting to target treatments to tumors by exploiting biological differences ...
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Theodore S. Lawrence
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1-2
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Signal transduction pathways: The molecular basis for targeted therapies
Abstract: The elucidation of the signal transduction pathways that regulate cell growth and differentiation has led to a number of exciting opportunities for novel cancer therapies. It is now well kno...
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Stephen P. Ethier
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3-10
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Epidermal growth factor receptor as a therapeutic target in head and neck cancer
Abstract: Epidermal growth factor receptor (EGFR) is a cell membrane protein that is overexpressed in almost all head and neck squamous cell carcinomas. Overexpression of EGFR has been associated with...
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James A. Bonner,
Jennifer De Los Santos,
Harlan W. Waksal,
Michael N. Needle,
Hoa Q. Trummel,
Kevin P. Raisch
et al.
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11-20
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Epidermal growth factor receptor modulation of radiation response: Preclinical and clinical development
Abstract: Approximately two thirds of all human solid tumors derive from epithelial tissues. The epidermal growth factor receptor (EGFR) serves as an important regulator of cellular growth in epitheli...
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Paul M. Harari,
Shyh-Min Huang
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21-26
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Farnesyltransferase inhibitors as radiation sensitizers
Abstract: Activation of Ras, by mutation, overexpression, or by signaling through tyrosine kinase receptors, is associated with radioresistance. Thus, therapies that inhibit Ras function could be an e...
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W.Gillies McKenna,
Ruth J. Muschel,
Anjali K. Gupta,
Stephen M. Hahn,
Eric J. Bernhard
et al.
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27-32
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Small-molecule tyrosine kinase inhibitors as radiosensitizers
Abstract: The discovery of a class of highly selective and potent compounds called the 4-anilinoquinazolines has led to the development of small-molecule tyrosine kinase inhibitors as potential antica...
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Theodore S. Lawrence,
Mukesh K. Nyati
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33-36
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CME test
Abstract: To view a print version of this article, click "View Print Version (PDF)" in the gray box on the right.
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A1
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Faculty disclosure
Abstract: To view a print version of this article, click "View Print Version (PDF)" in the gray box on the right.
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A1
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Unlabeled uses of commercial products or investigational uses not yet approved
Abstract: To view a print version of this article, click "View Print Version (PDF)" in the gray box on the right.
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A1
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Editorial Board
Supplement to Seminars in RADIATION ONCOLOGY
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