« Previous
Next »
Seminars in Radiation Oncology
Volume 20, Issue 4
, Pages 258-266
, October 2010
The E2F1/Rb and p53/MDM2 Pathways in DNA Repair and Apoptosis: Understanding the Crosstalk to Develop Novel Strategies for Prostate Cancer Radiotherapy
References
- . The dark side of a tumor suppressor: Anti-apoptotic p53. Cell Death Differ. 2008;15:959–976
- . p53 ubiquitination: Mdm2 and beyond. Mol Cell. 2006;21:307–315
- . Divorcing ARF and p53: An unsettled case. Nat Rev Cancer. 2006;6:663–673
- . Small-molecule antagonists of p53-MDM2 binding: Research tools and potential therapeutics. Cell Cycle. 2004;3:419–421
- . The RB and p53 pathways in cancer. Cancer Cell. 2002;2:103–112
- . The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair (Amst). 2004;3:1071–1079
- . p53 status and prognosis of locally advanced prostatic adenocarcinoma: A study based on RTOG 8610. and others J Natl Cancer Inst. 1997;89:158–165
- MDM2 as a predictor of prostate carcinoma outcome: An analysis of Radiation Therapy Oncology Group protocol 8610. Cancer. 2005;104:962–967
- Loss of p16 expression is of prognostic significance in locally advanced prostate cancer: An analysis from the Radiation Therapy Oncology Group protocol 86-10. J Clin Oncol. 2003;21:3328–3334
- Prognostic value of p16 in locally advanced prostate cancer: A study based on Radiation Therapy Oncology Group protocol 9202. J Clin Oncol. 2007;25:3082–3089
- Ki-67 staining index predicts distant metastasis and survival in locally advanced prostate cancer treated with radiotherapy: An analysis of patients in Radiation Therapy Oncology Group protocol 86-10. Clin Cancer Res. 2004;10:4118–4124
- Ki-67 staining is a strong predictor of distant metastasis and mortality for men with prostate cancer treated with radiotherapy plus androgen deprivation: Radiation Therapy Oncology Group trial 92-02. J Clin Oncol. 2004;22:2133–2140
- A 60 Kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells. Oncogene. 1998;17:2629–2636
- . Tumour suppression by p53: A role for the DNA damage response?. Nat Rev Cancer. 2009;9:714–723
- Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene. 2005;24:7238–7247
- Implication of p53 in base excision DNA repair: In vivo evidence. Oncogene. 2002;21:731–737
- Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell. 2004;13:627–638
- . Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements. Proc Natl Acad Sci U S A. 2005;102:4813–4818
- Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells. J Biol Chem. 2001;276:27363–27370
- . p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. Proc Natl Acad Sci U S A. 2002;99:12985–12990
- Mdm2 Regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell. 2008;32:180–189
- . E2F1 regulates autophagy and the transcription of autophagy genes. Oncogene. 2008;27:4860–4864
- Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat Cell Biol. 1999;1:14–19
- . An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell. 2008;13:11–22
- . Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001;15:1833–1844
- Mre11 Complex and DNA replication: Linkage to E2F and sites of DNA synthesis. Mol Cell Biol. 2001;21:6006–6016
- Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol Cell Biol. 2003;23:3287–3304
- . Transcription-independent p53 apoptosis: An alternative route to death. Trends Cell Biol. 2009;20:14–24Nos
- . p53 and E2F: Partners in life and death. Nat Rev Cancer. 2009;9:738–748
- Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 2004;303:1010–1014
- Mitochondrial p53 activates bak and causes disruption of a bak-Mcl1 complex. Nat Cell Biol. 2004;6:443–450
- p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003;11:577–590
- Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis. Science. 1998;282:290–293
- p14ARF links the tumour suppressors RB and p53. Nature. 1998;395:124–125
- . p14(ARF) regulates E2F activity. Oncogene. 2002;21:4220–4230
- Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 2000;407:645–648
- . Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Natl Acad Sci U S A. 2003;100:10848–10853
- Myc Signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 1998;12:2424–2433
- p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo. Mol Cell Biol. 2002;22:370–377
- E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis. Mol Cell Biol. 2002;22:5308–5318
- ARF differentially modulates apoptosis induced by E2F1 and Myc. Mol Cell Biol. 2002;22:1360–1368
- ARF is not required for apoptosis in Rb mutant mouse embryos. Curr Biol. 2002;12:159–163
- Adenoviral-E2F-1 radiosensitizes p53(wild-type) and p53(null) human prostate cancer cells. Int J Radiat Oncol Biol Phys. 2005;63:238–246
- MDM2 enhances E2F1-induced apoptosis and the combination sensitizes androgen-sensitive [corrected] and androgen-insensitive [corrected] prostate cancer cells to radiation. Mol Cancer Res. 2008;6:1742–1754
- Oncogenic capacity of the E2F1 gene. Proc Natl Acad Sci U S A. 1994;91:12823–12827
- Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage. Mol Cell Biol. 2002;22:78–93
- Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature. 1995;375:694–698
- Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature. 1995;375:691–694
- RB regulates the stability and the apoptotic function of p53 via MDM2. Mol Cell. 1999;3:181–193
- MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol Cell. 2005;20:699–708
- The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J Biol Chem. 2004;279:53317–53322
- E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ. 1998;9:113–118
- Adenovirus-mediated E2F-1 gene transfer inhibits MDM2 expression and efficiently induces apoptosis in MDM2-overexpressing tumor cells. Clin Cancer Res. 1999;5:2242–2250
- Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy. Proc Natl Acad Sci U S A. 2003;100:11636–11641
- . Mdm2 Inhibition of p53 induces E2F1 transactivation via p21. Oncogene. 2002;21:4414–4421
- Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. Curr Biol. 1997;7:860–869
- . p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene. 1997;15:1179–1189
- Therapeutic considerations for Mdm2: Not just a one trick pony. Expert Opin Drugs Discov. 2008;3:1309–1321
- Mdm2 Promotes genetic instability and transformation independent of p53. Mol Cell Biol. 2008;28:4862–4874
- MDM2 sensitizes prostate cancer cells to androgen deprivation, radiation, and the combination. Int J Radiat Oncol Biol Phys. 2004;58:336–343
- . Predictive models in external beam radiotherapy for clinically localized prostate cancer. Cancer. 2009;115:3112–3120(suppl)
- Bcl-2 and Bax expression and prostate cancer outcome in men treated with radiotherapy in Radiation Therapy Oncology Group protocol 86-10. Int J Radiat Oncol Biol Phys. 2006;66:25–30
- Loss of p16 expression is of prognostic significance in locally advanced prostate cancer: An analysis from the Radiation Therapy Oncology Group protocol 86-10. J Clin Oncol. 2003;21:3328–3334
- Protein kinase A RI-alpha predicts for prostate cancer outcome: Analysis of Radiation Therapy Oncology Group trial 86–10. Int J Radiat Oncol Biol Phys. 2008;71:1309–1315
- Prognostic value of survivin in locally advanced prostate cancer: Study based on RTOG 8610. Int J Radiat Oncol Biol Phys. 2009;73:1033–1042
- MDM2 and Ki-67 predict for distant metastasis and mortality in men treated with radiotherapy and androgen deprivation for prostate cancer RTOG, p 92, p 92. J Clin Oncol. 2009;27:3177–3184
- Prognostic value of abnormal p53 expression in locally advanced prostate cancer treated with androgen deprivation and radiotherapy: A study based on RTOG 9202. Int J Radiat Oncol Biol Phys. 2007;69:1117–1123
- Bcl-2 and Bax expression predict prostate cancer outcome in men treated with androgen deprivation and radiotherapy on Radiation Therapy Oncology Group protocol 92-02. Clin Cancer Res. 2007;13:3585–3590
- Cox-2 expression predicts prostate-cancer outcome: Analysis of data from the RTOG 92-02 trial. Lancet Oncol. 2007;8:912–920
- The importance of protein kinase A in prostate cancer: Relationship to patient outcome in Radiation Therapy Oncology Group Trial 92-02. Clin Cancer Res. 2009;15:5478–5484
- Short-term neoadjuvant androgen deprivation therapy and external-beam radiotherapy for locally advanced prostate cancer: Long-term results of RTOG 8610. J Clin Oncol. 2008;26:585–591
- Ten-year follow-up of Radiation Therapy Oncology Group protocol 92-02: A phase III trial of the duration of elective androgen deprivation in locally advanced prostate cancer. J Clin Oncol. 2008;26:2497–2504
- Phase III trial of long-term adjuvant androgen deprivation after neoadjuvant hormonal cytoreduction and radiotherapy in locally advanced carcinoma of the prostate: The Radiation Therapy Oncology Group Protocol 92-02. J Clin Oncol. 2003;21:3972–3978
- A model for distant metastasis incorporating tissue biomarkers from prostate cancer patients in Radiation Therapy Oncology Group (RTOG) 92-02. Boston. 2008;S58;p Supplement
- Expression of Bcl-2, p 53 and MDM2, in Localized Prostate Cancer with Respect to the Outcome of Radical Radiotherapy Dose Escalation. Int J Radiat Oncol Biol Phys. 2010;in press
PII: S1053-4296(10)00041-X
doi: 10.1016/j.semradonc.2010.05.007
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Radiation Oncology
Volume 20, Issue 4
, Pages 258-266
, October 2010
