Seminars in Radiation Oncology
Volume 20, Issue 3 , Pages 164-170 , July 2010

Image Guidance in Non–Small Cell Lung Cancer

  • B.C. John Cho, MD, PhD

      Affiliations

    • Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    • Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationAddress reprints requests to John Cho, MD, PhD, Department of Radiation Oncology, Princess Margaret Hospital, 610 University Av, Toronto, ON, Canada M5G 2M9
    • ,
  • Andrea Bezjak, MD

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    • ,
  • Laura A. Dawson, MD

      Affiliations

    • Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada

References 

  1. Balter JM. Image guided radiation therapy (IGRT)—A perspective, 2006. http://www.aapm.org/meetings/06SS/documents/2006summerschoolIGRTintro_000.pdfAccessed September 24, 2009
  2. Perez CA, Stanley K, Rubin P, et al. A prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung (Preliminary report by the Radiation Therapy Oncology Group). Cancer. 1980;45:2744–2753
  3. Perez CA, Pajak TF, Rubin P, et al. Long-term observations of the patterns of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy (Report by the Radiation Therapy Oncology Group). Cancer. 1987;59:1874–1881
  4. Fletcher GH. Clinical dose–response curves of human malignant epithelial tumours. Br J Radiol. 1973;46:1–12
  5. Onishi H, Araki T, Shirato H, et al. Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer. 2004;101:1623–1631
  6. Timmerman R, Papiez L, McGarry R, et al. Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer. Chest. 2003;124:1946–1955
  7. Xia T, Paulus R, Galvin J, et al. Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable stage I/II non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2006;66:117–125
  8. Sailer SL, Rosenman JG, Soltys M, et al. Improving treatment planning accuracy through multimodality imaging. Int J Radiat Oncol Biol Phys. 1996;35:117–124
  9. ICRU. Report 50: prescribing, recording and reporting photon beam therapy (I. Measurements, CoRUa). Bethesda, MD: ICRU; 1993;
  10. Giraud P, Elles S, Helfre S, et al. Conformal radiotherapy for lung cancer: different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologists. Radiother Oncol. 2002;62:27–36
  11. Senan S, van Sornsen de Koste J, Samson M, et al. Evaluation of a target contouring protocol for 3D conformal radiotherapy in non-small cell lung cancer. Radiother Oncol. 1999;53:247–255
  12. Arita T, Matsumoto T, Kuramitsu T, et al. Is it possible to differentiate malignant mediastinal nodes from benign nodes by size?: Reevaluation by CT, transesophageal echocardiography, and nodal specimen. Chest. 1996;110:1004–1008
  13. Prenzel KL, Monig SP, Sinning JM, et al. Lymph node size and metastatic infiltration in non-small cell lung cancer. Chest. 2003;123:463–467
  14. Pieterman RM, van Putten JW, Meuzelaar JJ, et al. Preoperative staging of non-small-cell lung cancer with positron-emission tomography. N Engl J Med. 2000;343:254–261
  15. Vanuytsel LJ, Vansteenkiste JF, Stroobants SG, et al. The impact of (18)F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) lymph node staging on the radiation treatment volumes in patients with non-small cell lung cancer. Radiother Oncol. 2000;55:317–324
  16. Zaidi H, Vees H, Wissmeyer M. Molecular PET/CT imaging-guided radiation therapy treatment planning. Acad Radiol. 2009;16:1108–1133
  17. Bradley J, horstad WL, Mutic S, et al. Impact of FDG-PET on radiation therapy volume delineation in non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2004;59:78–86
  18. MacManus MP, Nestle U, Rosenzweig KE, et al. Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006-07. Radiother Oncol. 2009;91:85–94
  19. Black QC, Grills IS, Kestin LL, et al. Defining a radiotherapy target with positron emission tomography. Int J Radiat Oncol Biol Phys. 2004;60:1272–1282
  20. Hong R, Halama J, Bova D, et al. Correlation of PET standard uptake value and CT window-level thresholds for target delineation in CT-based radiation treatment planning. Int J Radiat Oncol Biol Phys. 2007;67:720–726
  21. MacManus MP, Hicks RJ, Matthews JP, et al. Positron emission tomography is superior to computed tomography scanning for response-assessment after radical radiotherapy or chemoradiotherapy in patients with non-small-cell lung cancer. J Clin Oncol. 2003;21:1285–1292
  22. Sasaki R, Komaki R, Macapinlac H, et al. [18F]fluorodeoxyglucose uptake by positron emission tomography predicts outcome of non-small-cell lung cancer. J Clin Oncol. 2005;23:1136–1143
  23. Klopp AH, Chang JY, Tucker SL, et al. Intrathoracic patterns of failure for non-small-cell lung cancer with positron-emission tomography/computed tomography-defined target delineation. Int J Radiat Oncol Biol Phys. 2007;69:1409–1416
  24. Gambhir SS. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer. 2002;2:683–693
  25. Payne GS, Leach MO. Applications of magnetic resonance spectroscopy in radiotherapy treatment planning. Br J Radiol. 2006;79:S16–S26
  26. Bentzen SM. Radiation therapy: intensity modulated, image guided, biologically optimized and evidence based. Radiother Oncol. 2005;77:227–230
  27. Bentzen SM. Theragnostic imaging for radiation oncology: Dose-painting by numbers. Lancet Oncol. 2005;6:112–117
  28. Ling CC, Humm J, Larson S, et al. Toards multidimensional radiotherapy (MD-CRT): Biological imaging and biological conformality. Int J Radiat Oncol Biol Phys. 2000;47:551–560
  29. Thorwarth D, Eschmann SM, Paulsen F, et al. Hypoxia dose painting by numbers: a planning study. Int J Radiat Oncol Biol Phys. 2007;68:291–300
  30. Giraud P, Antoine M, Larrouy A, et al. Evaluation of microscopic tumor extension in non-small-cell lung cancer for three-dimensional conformal radiotherapy planning. Int J Radiat Oncol Biol Phys. 2000;48:1015–1024
  31. Grills IS, Fitch DL, Goldstein NS, et al. Clinicopathologic analysis of microscopic extension in lung adenocarcinoma: Defining clinical target volume for radiotherapy. Int J Radiat Oncol Biol Phys. 2007;69:334–341
  32. Belderbos JS, Kepka L, Spring Kong FM, et al. Report from the International Atomic Energy Agency (IAEA) consultants' meeting on elective nodal irradiation in lung cancer: Non-small-cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 2008;72:335–342
  33. Kwa SL, Lebesque JV, Theuws JC, et al. Radiation pneumonitis as a function of mean lung dose: An analysis of pooled data of 540 patients. Int J Radiat Oncol Biol Phys. 1998;42:1–9
  34. Belderbos JS, Kepka L, Kong FM, et al. Elective nodal irradiation (ENI) in locally advanced non-small-cell lung cancer (NSCLC): evidence versus opinion?. Int J Radiat Oncol Biol Phys. 2009;74:322
  35. Grills IS, Yan D, Martinez AA, et al. Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation. Int J Radiat Oncol Biol Phys. 2003;57:875–890
  36. Belderbos JS, Heemsbergen WD, De Jaeger K, et al. Final results of a Phase I/II dose escalation trial in non-small-cell lung cancer using three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 2006. 2006;66:126–134
  37. De Ruysscher D, Wanders S, van Haren E, et al. Selective mediastinal node irradiation based on FDG-PET scan data in patients with non-small-cell lung cancer: A prospective clinical study. Int J Radiat Oncol Biol Phys. 2005;62:988–994
  38. Kong FM, Ten Haken RK, Schipper MJ, et al. High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: long-term results of a radiation dose escalation study. Int J Radiat Oncol Biol Phys. 2005;63:324–333
  39. Jeremic B. Incidental irradiation of nodal regions at risk during limited-field radiotherapy (RT) in dose-escalation studies in nonsmall cell lung cancer (NSCLC) (Enough to convert no-elective into elective nodal irradiation (ENI)?). Radiother Oncol. 2004;71:123–125
  40. Martel MK, Sahijdak WM, Hayman JA, et al. 186 Incidental dose to clinically negative nodes from conformal treatment fields for nonsmall cell lung cancer. Int J Radiat Oncol Biol Phys. 1999;45:244
  41. Chen ZL, Perez S, Holmes EC, et al. Frequency and distribution of occult micrometastases in lymph nodes of patients with non-small-cell lung carcinoma. J Natl Cancer Inst. 1993;85:493–498
  42. Passlick B, Izbicki JR, Kubuschok B, et al. Detection of disseminated lung cancer cells in lymph nodes: impact on staging and prognosis. Ann Thorac Surg. 1996;61:177–182
  43. Dwamena BA, Sonnad SS, Angobaldo JO, et al. Metastases from non-small cell lung cancer: mediastinal staging in the 1990s—meta-analytic comparison of PET and CT. Radiology. 1999;213:530–536
  44. Gould MK, Kuschner WG, Rydzak CE, et al. Test performance of positron emission tomography and computed tomography for mediastinal staging in patients with non-small-cell lung cancer: a meta-analysis. Ann Intern Med. 2003;139:879–892
  45. Gould MK, Maclean CC, Kuschner WG, et al. Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis. JAMA. 2001;285:914–924
  46. Suzuki K, Nagai K, Yoshida J, et al. Clinical predictors of N2 disease in the setting of a negative computed tomographic scan in patients with lung cancer. J Thorac Cardiovasc Surg. 1999;117:593–598
  47. Chang JY, Dong L, Liu H, et al. Image-guided radiation therapy for non-small cell lung cancer. J Thorac Oncol. 2008;3:177–186
  48. ICRU Report 62: Prescribing, recording and reporting phonton beam therapy (Supplement to ICRU Report 50), I.C.o.R.U.a. Measurements. Bethesda, MD: ICRU; 1999;
  49. Nehmeh SA, et al. Four-dimensional (4D) PET/CT imaging of the thorax. Med Phys. 2004;31:3179–3186
  50. Ezhil M, Vedam S, Choi B, et al. Determination of patient-specific intra-fractional respiratory motion envelope of tumors from maximum intensity projections of 4D CT datasets. Int J Radiat Oncol Biol Phys. 2007;69:S484–S485
  51. Wolthaus JW, Schneider C, Sonke JJ, et al. Mid-ventilation CT scan construction from four-dimensional respiration-correlated CT scans for radiotherapy planning of lung cancer patients. Int J Radiat Oncol Biol Phys. 2006;65:1560–1571
  52. Gagel B, Demirel C, Kientopf A, et al. Active breathing control (ABC): Determination and reduction of breathing-induced organ motion in the chest. Int J Radiat Oncol Biol Phys. 2007;67:742–749
  53. Rosenzweig KE, Hanley J, Mah D, et al. The deep inspiration breath-hold technique in the treatment of inoperable non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2000;48:81–87
  54. Ramsey CR, Scaperoth D, Arwood D, et al. Clinical efficacy of respiratory gated conformal radiation therapy. Med Dosim. 1999;24:115–119
  55. Liu HH, Balter P, Tutt T, et al. Assessing respiration-induced tumor motion and internal target volume using four-dimensional computed tomography for radiotherapy of lung cancer. Int J Radiat Oncol Biol Phys. 2007;68:531–540
  56. van Herk M. Errors and margins in radiotherapy. Semin Radiat Oncol. 2004;14:52–64
  57. Mehta M, Scrimger R, Mackie R, et al. A new approach to dose escalation in non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2001;49:23–33
  58. Verellen D, Linthout N, Soete G, et al. Considerations on treatment efficiency of different conformal radiation therapy techniques for prostate cancer. Radiother Oncol. 2002;63:27–36
  59. Hugo GD, Yan D, Liang J. Population and patient-specific target margins for 4D adaptive radiotherapy to account for intra- and inter-fraction variation in lung tumour position. Phys Med Biol. 2007;52:257–274
  60. De Neve W, Van den Heuvel F, De Beukeleer M, et al. Routine clinical on-line portal imaging followed by immediate field adjustment using a tele-controlled patient couch. Radiother Oncol. 1992;24:45–54
  61. Ezz A, Munro P, Porter AT, et al. Daily monitoring and correction of radiation field placement using a video-based portal imaging system: a pilot study. Int J Radiat Oncol Biol Phys. 1992;22:159–165
  62. Bel A, Petrascu O, Van de Vondel I, et al. A computerized remote table control for fast on-line patient repositioning: Implementation and clinical feasibility. Med Phys. 2000;27:354–358
  63. Hansen VN, Evans PM, Swindell W. The application of transit dosimetry to precision radiotherapy. Med Phys. 1996;23:713–721
  64. Pasma KL, Heijmen BJ, Kroonwijk M, et al. Portal dose image (PDI) prediction for dosimetric treatment verification in radiotherapy (I. An algorithm for open beams). Med Phys. 1998;25:830–840
  65. Seppenwoolde Y, Shirato H, Kitamura K, et al. Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. Int J Radiat Oncol Biol Phys. 2002;53:822–834
  66. Shirato H, Shimizu S, Kitamura K, et al. Four-dimensional treatment planning and fluoroscopic real-time tumor tracking radiotherapy for moving tumor. Int J Radiat Oncol Biol Phys. 2000;48:435–442
  67. Whyte RI, Crownover R, Murphy MJ, et al. Stereotactic radiosurgery for lung tumors: preliminary report of a phase I trial. Ann Thorac Surg. 2003;75:1097–1101
  68. Mackie TR, Kapatoes J, Ruchala K, et al. Image guidance for precise conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2003;56:89–105
  69. Jaffray DA, Drake DG, Moreau M, et al. A radiographic and tomographic imaging system integrated into a medical linear accelerator for localization of bone and soft-tissue targets. Int J Radiat Oncol Biol Phys. 1999;45:773–789
  70. Jaffray DA, Siewerdsen JH, Wong JW, et al. Flat-panel cone-beam computed tomography for image-guided radiation therapy. Int J Radiat Oncol Biol Phys. 2002;53:1337–1349
  71. Higgins J, Bezjak A, Franks K, et al. Comparison of spine, Carina and tumor as registration landmarks for volumetric image-guided lung radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73:1404–1413
  72. Bissonnette JP, Purdie TG, Higgins JA, et al. Cone-beam computed tomographic image guidance for lung cancer radiation therapy. Int J Radiat Oncol Biol Phys. 2009;73:927–934
  73. Wang Z, Nelson JW, Yoo S, et al. Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73:571–577
  74. Rosenzweig KE, Amols H, Ling CC. New radiotherapy technologies. Semin Surg Oncol. 2003;21:190–195
  75. Sonke JJ, Zijp L, Remeijer P, et al. Respiratory correlated cone beam CT. Med Phys. 2005;32:1176–1186
  76. Bissonnette JP, Franks KN, Purdie TG, et al. Quantifying interfraction and intrafraction tumor motion in lung stereotactic body radiotherapy using respiration-correlated cone beam computed tomography. Int J Radiat Oncol Biol Phys. 2009;75:688–695
  77. Sonke JJ, Rossi M, Wolthaus J, et al. Frameless stereotactic body radiotherapy for lung cancer using four-dimensional cone beam CT guidance. Int J Radiat Oncol Biol Phys. 2009;74:567–574
  78. Birkner M, Yan D, Alber M, et al. Adapting inverse planning to patient and organ geometrical variation: Algorithm and implementation. Med Phys. 2003;30:2822–2831
  79. Yan D, Vicini F, Wong J, et al. Adaptive radiation therapy. Phys Med Biol. 1997;42:123–132
  80. Lim GW, Bezjak A, Higgins J, et al. Respiratory correlated cone beam CT in the assessment of non-small cell lung cancer during radiotherapy. Int J Radiat Oncol Biol Phys. 2008;72(suppl 1):S430–S431
  81. Kupelian PA, Ramsey C, Meeks SL, et al. Serial megavoltage CT imaging during external beam radiotherapy for non-small-cell lung cancer: observations on tumor regression during treatment. Int J Radiat Oncol Biol Phys. 2005;63:1024–1028
  82. Ramsey CR, Langen KM, Kupelian PA, et al. A technique for adaptive image-guided helical tomotherapy for lung cancer. Int J Radiat Oncol Biol Phys. 2006;64:1237–1244
  83. Siker ML, Tome WA, Mehta MP. Tumor volume changes on serial imaging with megavoltage CT for non-small-cell lung cancer during intensity-modulated radiotherapy: how reliable, consistent, and meaningful is the effect?. Int J Radiat Oncol Biol Phys. 2006;66:135–141
  84. Woodford C, Yartsev S, Dar AR, et al. Adaptive radiotherapy planning on decreasing gross tumor volumes as seen on megavoltage computed tomography images. Int J Radiat Oncol Biol Phys. 2007;69:1316–1322
  85. Cho BJ, Bezjak A, Brade A, et al. Quantifying the benefits of adaptive radiotherapy on lung sparing for thoracic tumors. Int J Radiat Oncol Biol Phys. 2008;72:S446–S447
  86. Feng M, Kong FM, Gross M, et al. Using fluorodeoxyglucose positron emission tomography to assess tumor volume during radiotherapy for non-small-cell lung cancer and its potential impact on adaptive dose escalation and normal tissue sparing. Int J Radiat Oncol Biol Phys. 2009;73:1228–1234
  87. Gillham C, Zips D, Ponisch F, et al. Additional PET/CT in week 5-6 of radiotherapy for patients with stage III non-small cell lung cancer as a means of dose escalation planning?. Radiother Oncol. 2008;88:335–341

PII: S1053-4296(10)00014-7

doi: 10.1016/j.semradonc.2010.01.006

Seminars in Radiation Oncology
Volume 20, Issue 3 , Pages 164-170 , July 2010

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