Seminars in Radiation Oncology
Volume 20, Issue 1 , Pages 52-57 , January 2010

Head and Neck Carcinomas Across the Age Spectrum: Epidemiology, Therapy, and Late Effects

  • Karen J. Marcus, MD

      Affiliations

    • Division of Radiation Oncology, Children's Hospital Boston, Boston, MA
    • Corresponding Author InformationAddress reprint requests to Karen J. Marcus, MD, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115
  • ,
  • Roy B. Tishler, MD, PhD

      Affiliations

    • Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

References 

  1. Deutsch M, Mercado R, Parsons JA. Cancer of the nasopharynx in children. Cancer. 1978;41:1128–1133
  2. Ingersoll L, Woo SY, Donaldson S. Nasopharyngeal carcinoma in the young: A combined M.D. Anderson and Stanford experience. Int J Radiat Oncol Biol Phys. 1990;19:881–887
  3. Mertens R, Granzen B, Lassay L. Nasopharyngeal carcinoma in childhood and adolescence: Concept and preliminary results of the cooperative GPOH study NPC-91 (Gesellschaft fur Padiatrische Onkologie und Hamatologie). Cancer. 1997;80:951–959
  4. Bray F, Haugen M, Moger TA. Age-incidence curves of nasopharyngeal carcinoma worldwide: Bimodality in low-risk populations and aetiologic implications. Cancer Epidemiol Biomarkers Prev. 2008;17:2356–2365
  5. Ayan I, Altun M. Nasopharyngeal carcinoma in children: Retrospective review of 50 patients. Int J Radiat Oncol Biol Phys. 1996;35:485–492
  6. Levine PH, Connelly RR, Easton JM. Demographic patterns for nasopharyngeal carcinoma in the United States. Int J Cancer. 1980;26:741–748
  7. Har-Kedar I, Chaitchik S, Hercberg A. Nasopharyngeal carcinoma at the Tel-Hashomer Government Hospital, Israel (A 20 year survey (1951-1970)). Clin Radiol. 1974;25:403–407
  8. Hu DE, Ling XS, Hu J. The effects of radiotherapy on the immune system of patients with nasopharyngeal carcinoma. Br J Radiol. 1988;61:305–308
  9. Vasef MA, Ferlito A, Weiss LM. Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein–Barr virus. Ann Otol Rhinol Laryngol. 1997;106:348–356
  10. Cohen JI. Epstein–Barr virus infection. N Engl J Med. 2000;343:481–492
  11. Preciado MV, Chabay PA, De Matteo EN. Epstein Barr virus associated pediatric nasopharyngeal carcinoma: Its correlation with p53 and bcl-2 expression. Med Pediatr Oncol. 2002;38:345–348
  12. Vokes EE, Liebowitz DN, Weichselbaum RR. Nasopharyngeal carcinoma. Lancet. 1997;350:1087–1091
  13. Claudio PP, Howard CM, Fu Y. Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma. Cancer Res. 2000;60:8–12
  14. Wang CC. Radiation Therapy for Head and Neck Neoplasms. (ed 3). New York, NY: Wiley-Liss; 1997;
  15. Stambuk HE, Patel SG, Mosier KM. Nasopharyngeal carcinoma: Recognizing the radiographic features in children. Am J Neuroradiol. 2005;26:1575–1579
  16. Fleming I, Cooper J, Henson D. AJCC Cancer Staging Manual. (ed 5). Philadelphia, PA: Lippincott-Raven; 1997;
  17. Wolden SL, Steinherz PG, Kraus DH. Improved long-term survival with combined modality therapy for pediatric nasopharynx cancer. Int J Radiat Oncol Biol Phys. 2000;46:859–864
  18. Ayan I, Kaytan E, Ayan N. Childhood nasopharyngeal carcinoma: From biology to treatment. Lancet Oncol. 2003;4:13–21
  19. Zubizarreta PA, D'Antonio G, Raslawski E. Nasopharyngeal carcinoma in childhood and adolescence: A single-institution experience with combined therapy. Cancer. 2000;89:690–695
  20. Wolden SL, Chen WC, Pfister DG. Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: Update of the Memorial Sloan-Kettering experience. Int J Radiat Oncol Biol Phys. 2006;64:57–62
  21. Laskar S, Bahl G, Muckaden M. Nasopharyngeal carcinoma in children: Comparison of conventional and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2008;72:728–736
  22. Al-Sarraf M, LeBlanc M, Giri PG. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized intergroup study 0099. J Clin Oncol. 1998;16:1310–1317
  23. Ma J, Mai HQ, Hong MH. Results of a prospective randomized trial comparing neoadjuvant chemotherapy plus radiotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma. J Clin Oncol. 2001;19:1350–1357
  24. Chan AT, Teo PM, Ngan RK. Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: Progression-free survival analysis of a phase III randomized trial. J Clin Oncol. 2002;20:2038–2044
  25. Chan AT, Leung SF, Ngan RK. Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst. 2005;97:536–539
  26. Baujat B, Audry H, Bourhis J. Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys. 2006;64:47–56
  27. Hui EP, Ma BB, Leung SF. Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma. J Clin Oncol. 2009;27:242–249
  28. Jenkin RD, Anderson JR, Jereb B. Nasopharyngeal carcinoma—a retrospective review of patients less than thirty years of age: A report of Children's Cancer Study Group. Cancer. 1981;47:360–366
  29. Varan A, Ozyar E, Corapcioglu F. Pediatric and young adult nasopharyngeal carcinoma patients treated with preradiation cisplatin and docetaxel chemotherapy. Int J Radiat Oncol Biol Phys. 2009;73:1116–1120
  30. Lombardi F, Gasparini M, Gianni C. Nasopharyngeal carcinoma in childhood. Med Pediatr Oncol. 1982;10:243–250
  31. Uzel O, Yoruk SO, Sahinler I. Nasopharyngeal carcinoma in childhood: Long-term results of 32 patients. Radiother Oncol. 2001;58:137–141

PII: S1053-4296(09)00065-4

doi: 10.1016/j.semradonc.2009.09.004

Seminars in Radiation Oncology
Volume 20, Issue 1 , Pages 52-57 , January 2010