Seminars in Radiation Oncology
Volume 19, Issue 4 , Pages 244-255 , October 2009

Radiation Techniques and Toxicities for Locally Advanced Breast Cancer

  • Meena S. Moran, MD

      Affiliations

    • Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT
    • Corresponding Author InformationAddress reprint requests to Meena S. Moran, MD, Yale University School of Medicine, 333 Cedar Street, PO Box 208040, New Haven, CT 06520-8040
  • ,
  • Bruce G. Haffty, MD

      Affiliations

    • Department of Radiation Oncology, UMDNJ-Robert Wood Johnson School of Medicine, New Brunswick, NJ
    • The Cancer Institute of New Jersey, New Brunswick, NJ

References 

  1. Ragaz J, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med. 1997;337:956–962
  2. Overgaard M, Hansen PS, Overgaard J, et al. Postoperative radiotherapy in high-risk premenopausal women with breast Cancer who receive adjuvant chemotherapy (Danish Breast Cancer Cooperative Group, p 82b Trial). N Engl J Med. 1997;337:949–955
  3. Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomized trial. Lancet. 1999;353:1641–1648
  4. Taghian A, Jagsi R, Makris A, et al. Results of a survey regarding irradiation of internal mammary chain in patients with breast cancer: Practice is culture driven rather than evidence based. Int J Radiat Oncol Biol Phys. 2004;60:706–714
  5. Taylor ME, Haffty BG, Shank BM, et al. Postmastectomy radiotherapy; American College of Radiology, ACR: Appropriateness criteria. Radiology. 2000;215(suppl):1153–1170
  6. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–1241
  7. White J, Moughan J, Pierce LJ, et al. Status of post-mastectomy radiotherapy in the United States: A patterns of care study. Int J Radiat Oncol Biol Phys. 2004;60:77–85
  8. Bornstein BA, Cheng CW, Rhodes LM, et al. Can simulation measurements be used to predict the irradiated lung volume in the tangential fields in patients treated for breast cancer?. Int J Radiat Oncol Biol Phys. 1990;18:181–187
  9. Kirova YM, Campana F, Fournier-Bidoz N, et al. Postmastectomy electron beam chest wall irradiation in women with breast cancer: A clinical step toward conformal electron therapy. Int J Radiat Oncol Biol Phys. 2007;69:1139–1144
  10. Kirova YM, Campana F, Fournier-Bidoz N, et al. Post-mastectomy electron beam chest wall irradiation in women with breast cancer: A clinical step toward conformal electron therapy. Int J Radiat Oncol Biol Phys. 2007;69:1139–1144
  11. Pierce LJ, Butler JB, Martel MK, et al. Postmastectomy radiotherapy of the chest wall: Dosimetric comparison of common techniques. Int J Radiat Oncol Biol Phys. 2002;52:1220–1230
  12. Hartsell WF, Kelly CA, Schneider L, et al. A single isocenter three-field breast irradiation technique using an empiric simulation and a symmetric collimator. Med Dosimetry. 1994;19:169–173
  13. Chu JC, Solin LJ, Hwang CC, et al. A nondivergent three field matching technique for breast irradiation. Int J Radiat Oncol Biol Phys. 1990;19:1037–1040
  14. Svensson GK, Bjarngard BE, Larsen RD, et al. A modified three-dimensional technique for breast treatment. Int J Radiat Oncol Biol Phys. 1980;6:689–694
  15. Svensson GK, Chin LM, Siddon RL, et al. Breast treatment techniques at the Joint Center for Radiation Therapy. In:  Harris JR,  Hellman S,  Silen W editor. Conservative Management of Breast Cancer: New Surgical and Radiotherapeutic Techniques. Philadelphia: JB Lippincott; 1983;p. 239–255
  16. Siddon RL, Buck BA, Harris JR, et al. Three-field technique for breast irradiation using tangential field corner blocks. Int J Radiat Oncol Biol Phys. 1983;9:583–588
  17. Lebesque JV. Field matching in breast irradiation: An exact solution to a geometrical problem. Radiother Oncol. 1986;5:47–57
  18. Podgorsak EB, Gosselin M, Kim TH, et al. A simple isocentric technique for irradiation of the breast, chest wall and peripheral lymphatics. Br J Radiol. 1984;57:57–63
  19. Garg AK, Frija EK, Sun TL, et al. Effects of variable placement of superior tangential/supraclavicular match line on dosimetric coverage of level III axilla/axillary apex in patients treated with breast and supraclavicular radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73:370–374
  20. Liengsawangwong R, Yu TK, Sun TL, et al. Treatment optimization using computed tomography-delineated targets should be used for supraclavicular irradiation for breast cancer. Int J Radiat Oncol Biol Phys. 2007;69:711–715
  21. Bentel GC, Marks LB, Hardenbergh PH, et al. Variability of the depth of supraclavicular and axillary lymph nodes in patients with breast cancer: Is a posterior axillary boost field necessary?. Int J Radiat Oncol Biol Phys. 2000;47:755–758
  22. Pignol JP, Olivotto I, Rakovitch E, et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol. 2008;26:2085–2092
  23. Donovan E, Bleakley N, Denholm E, et al. Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol. 2007;82:254–264
  24. Fraass BA, Kessler ML, McShan DL, et al. Optimization and clinical use of multisegment intensity-modulated radiation therapy for high-dose conformal therapy. Semin Radiat Oncol. 1999;9:60–77
  25. White J, Tai A, Arthur D, et al: RTOG breast cancer atlas for radiation therapy planning: Consensus definitions: Presented at the ASCO 2008 Breast Cancer Symposium, Washington DC, 2008
  26. Buchholtz TA. Breast cancer. In:  Chao C,  Apisrathanarax S,  Ozyigit G editor. Practical Essentials of Intensity Modulated Radiation Therapy. Philadelphia, PA: Lippincott, Williams & Wilkins; 2005;p. 248
  27. Cuzick J, Stewart H, Rutqvist L, et al. Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol. 1994;12:447–453
  28. Early Breast Cancer Realists Collaborative Group. Effects of radiotherapy and surgery in early breast cancer: An overview of the randomized trials. N Engl J Med. 1995;333:1444–1455
  29. Paszat LF, Mackillop WJ, Groome PA, et al. Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries. J Clin Oncol. 1998;16:2625–2631
  30. Rutqvist LE, Johansson H. Mortality by laterality of the primary tumour among 55,000 breast cancer patients from the Swedish Cancer Registry. Br J Cancer. 1990;61:866–868
  31. EBCTCG. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: An overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet. 2000;355:1757–1770
  32. Host H, Brennhovd IO, Loeb M. Postoperative radiotherapy in breast cancer—Long-term results from the Oslo study. Int J Radiat Oncol Biol Phys. 1986;12:727–732
  33. Early Breast Cancer Trialists' Collaborative Group. In: Treatment of Early Breast Cancer: Worldwide Evidence 1985-1990. vol 1:Oxford: Oxford University Press; 1990;
  34. Jones J, Ribeiro G. Mortality patterns over 34 years of breast cancer patients in a clinical trial of post-operative radiotherapy. Clin Radiol. 1989;40:204–208
  35. Haybittle JL, Brinkley D, Houghton J, et al. Postoperative radiotherapy and late mortality: Evidence from the cancer research campaign trial for early breast cancer. BMJ. 1989;298:1611–1614
  36. Giordano SH, Kuo YF, Freeman JL, et al. Risk of cardiac death after adjuvant radiotherapy for breast cancer. J Natl Cancer Inst. 2005;97:419–424
  37. Fuller SA, Haybittle JL, Smith RE, et al. Cardiac doses in post-operative breast irradiation. Radiother Oncol. 1992;25:19–24
  38. Muren LP, Maurstad G, Hafslund R, et al. Cardiac and pulmonary doses and complication probabilities in standard and conformal tangential irradiation in conservative management of breast cancer. Radiother Oncol. 2002;62:173–183
  39. Hurkmans CW, Borger JH, Bos LJ, et al. Cardiac and lung complication probabilities after breast cancer irradiation. Radiother Oncol. 2000;55:145–151
  40. Hurkmans CW, Cho BC, Damen E, et al. Reduction of cardiac and lung complication probabilities after breast irradiation using conformal radiotherapy with or without intensity modulation. Radiother Oncol. 2002;62:163–171
  41. Clarke M, Collins R, Darby S, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet. 2005;366:2087–2106
  42. Hojris I, Overgaard M, Christensen JJ, et al. Morbidity and mortality of ischemic heart disease in high-risk breast-cancer after adjuvant postmastectomy systemic treatment with or without radiotherapy: Analysis of DBCG 82b and 82c randomized trails. Lancet. 1999;354:1425–1430
  43. Taylor C, McGale P, Povall J, et al. Estimating cardiac exposure from breast cancer radiotherapy in clinical practice. Int J Radiat Oncol Biol Phys Octoer. 2009;73:1061–1068
  44. Gagliardi G, Lax I, Rutqvist LE. Partial irradiation of the heart. Semin Radiat Oncol. 2001;11:224–233
  45. Lu HM, Cash E, Chen MH, et al. Reduction of cardiac volume in left-breast treatment fields by respiratory maneuvers: A CT study. Int J Radiat Oncol Biol Phys. 2000;47:895–904
  46. Korreman SS, Pedersen AN, Nottrup TJ, et al. Breathing adapted radiotherapy for breast cancer: Comparison of free breathing gating with the breath-hold technique. Radiother Oncol. 2005;76:311–318
  47. Remouchamps VM, Vicini FA, Sharpe MB, et al. Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity modulated radiation therapy for patients treated with locoregional breast irradiation. Int J Radiat Oncol Biol Phys. 2003;55:392–406
  48. Canney PA, Deehan C, Glegg M, et al. Reducing cardiac dose in post-operative irradiation of breast cancer patients: The relative importance of patient positioning and CT scan planning. Br J Radiol. 1999;72:986–993
  49. Canney PA, Sanderson R, Deehan C, et al. Variation in the probability of cardiac complications with radiation technique in early breast cancer. Br J Radiol. 2001;74:262–265
  50. Formenti SC, Truong MT, Goldberg JD, et al. Prone accelerated partial breast irradiation after breast-conserving surgery: Preliminary clinical results and dose-volume histogram analysis. Int J Radiat Oncol Biol Phys. 2004;60:493–504
  51. Griem KL, Fetherston P, Kuznetsova M, et al. Three-dimensional photon dosimetry: A comparison of treatment of the intact breast in the supine and prone position. Int J Radiat Oncol Biol Phys. 2003;57:891–899
  52. Gyenes G, Gagliardi G, Lax I, et al. Evaluation of irradiated heart volumes in stage I breast cancer patients treated with postoperative adjuvant radiotherapy. J Clin Oncol. 1997;15:1348–1353
  53. Yahalom J, Portlock CS. Cancer: Principles and Practice of Oncology. (ed 7). Philadelphia, PA: Lippincott/Williams & Wilkins; 2005;
  54. Belkacemi Y, Gligorov J, Ozsahin M, et al. Concurrent trastuzamab with adjuvant radiotherapy in HER2-positive breast cancer patients: Acute toxicity analyses from the French multicentric study. Ann Oncol. 2008;19:1110–1116
  55. Lingos TI, Recht A, Vicini F, et al. Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 1991;21:355–360
  56. Kimsey FC, Mendenhall NP, Ewald LM, et al. Is radiation treatment volume a predictor for acute or late effects on pulmonary function? (A prospective study of patients treated with breast-conserving surgery and post-operative irradiation). Cancer. 1994;73:2549–2555
  57. Lind P, Wennberg B, Gagliardi G, et al. Pulmonary complications following different radiotherapy techniques for breast cancer, and the association to irradiated lung volume and dose. Br Cancer Res Treat. 2001;68:199–210
  58. Krengli M, Sacco M, Loi G, et al. Pulmonary changes after radiotherapy for conservative treatment of breast cancer: A prospective study. Int J Radiat Oncol Biol Phys. 2008;70:1460–1467
  59. Kissin MW, Querci della Rovere G, Easton D, et al. Risk of lymphedema following treatment for breast cancer. Br J Surg. 1986;73:580–584
  60. Dewar JA, Sarrazin D, Benhamou E, et al. Management of the axilla in conservatively treated breast cancer: 592 patients treated at the institue Gustave-Roussy. Int J Radiat Oncol Biol Phys. 1987;13:475–481
  61. Hayes SB, Freedman GM, Li T, et al. Does axillary boost increase lymphedema compared with supraclavicular radiation alone after breast conservation?. Int J Radiat Oncol Biol Phys. 2008;72:1449–1455
  62. Leitch A, Meek A, Smith R, et al. Workgroup I: Treatment of the axilla with surgery and radiation-preoperative and postoperative risk assessment. Cancer. 1998;S83:2877–2879
  63. Svensson H, Westling P, Larsson L-G. Radiation-induced lesions of the brachial plexus correlated to the dose-time-fractionation schedule. Acta Radiol Ther Phys Biol. 1975;14:228–238
  64. Benson S, Dische S. Morbidity related to axillary irradiation in the treatment of breast cancer. Acta Oncol. 2000;39:337–347

PII: S1053-4296(09)00044-7

doi: 10.1016/j.semradonc.2009.05.007

Seminars in Radiation Oncology
Volume 19, Issue 4 , Pages 244-255 , October 2009