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Seminars in Radiation Oncology
Volume 19, Issue 3
, Pages 171-178
, July 2009
Molecular Advances of Brain Tumors in Radiation Oncology
References
- . Statistical report: Primary brain tumors in the United States, 1998-2002. Chicago, IL: CBTRUS; 2006;
- WHO classification of tumours of the central nervous system. (ed 4). IARC, Lyon: World Health Organization; 2007;
- Validation and predictive power of Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis classes for malignant glioma patients: A report using RTOG 90-06. Int J Radiat Oncol Biol Phys. 1998;40:51–55
- Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme. J Neurooncol. 2008;89:97–103
- A prospective study on glioblastoma in the elderly. Cancer. 2003;97:657–662
- Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patients. Int J Radiat Oncol Biol Phys. 2008;70:987–992
- Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J Neurooncol. 2008;88:97–103
- Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987–996
- A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival. J Neurosurg. 2001;95:190–198
- Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer. 1993;71:2585–2597
- . Current management of glioblastoma multiforme. Semin Oncol. 2004;31:635–644
- . Neuro-oncology: The growing role of chemotherapy in glioma. Lancet Neurol. 2005;4:4–5
- Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10:459–466
- . New treatment strategies for malignant gliomas. Expert Rev Anticancer Ther. 2006;6:1087–1104
- . Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol. 2005;64:479–489
- Glioblastoma multiforme and anaplastic astrocytoma (Pathologic criteria and prognostic implications). Cancer. 1985;56:1106–1111
- Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res. 2000;60:417–424
- Comprehensive allelotype and genetic analysis of 466 human nervous system tumors. J Neuropathol Exp Neurol. 2000;59:544–558
- Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas. Brain Pathol. 1999;9:435–442
- CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res. 1994;54:6321–6324
- Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. Cancer Res. 1994;54:4299–4303
- . Primary and secondary glioblastomas: From concept to clinical diagnosis. J Neuro Oncol. 1999;1:44–51
- . Chemotherapy in adult high-grade glioma: A systematic review and metal-analysis of individual patient data from 12 randomised trials. Lancet. 2002;359:1011–1018
- Metaanalysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer. 1993;71:2585–2597
- Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of highgrade astrocytoma: A Medical Research Council trial. J Clin Oncol. 2001;19:509–518
- . MGMT: Its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer. 2004;4:296–307
- MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352:997–1003
- Molecularly targeted therapy for malignant glioma. Cancer. 2007;110:13–24
- Temozolomide-mediated radiation enhancement in glioblastoma: A report on underlying mechanisms. Clin Cancer Res. 2006;12:4738–4746
- In vitro evaluation of temozolomide combined with X-irradiation. Anticancer Drugs. 1997;8:92–97
- SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res. 2003;63:4009–4016
- Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma. Clin Cancer Res. 2005;11:835–842
- Synergistic antiglioma activity of radiotherapy and enzastaurin. Ann Neurol. 2007;61:153–161
- Anti-epidermal growth factor receptor monoclonal antibody cetuximab augments radiation effects in glioblastoma multiforme in vitro and in vivo. Neurosurgery. 2005;56:155–162
- STI571 (Gleevec) improves tumor growth delay and survival in irradiated mouse models of glioblastoma. Int J Radiat Oncol Biol Phys. 2006;64:263–271
- HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway. Cancer Res. 2006;66:6756–6762
- PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization. Neurosurgery. 2004;55:426–432
- Survival of human glioma cells treated with various combination of temozolomide and X-rays. Int J Radiat Oncol Biol Phys. 2000;47:779–784
- Malignant astrocytic glioma: Genetics, biology, and paths to treatment. Genes Dev. 2007;21:2683–2710
- . Oligodendroglioma: Toward molecular definitions in diagnostic neuro-oncology. J Neuropathol Exp Neurol. 2003;62:111–126
- . Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3′-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas. Brain Pathol. 2003;13:507–518
- The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol. 2004;22:1926–1933
- . Angiogenesis: An organizing principle for drug discovery?. Nat Rev Drug Discov. 2007;6:273–286
- . The contribution of epidermal growth factor receptor (EGFR) signaling pathway to radioresistance in human gliomas: A review of preclinical and correlative clinical data. Int J Radiat Oncol Biol Phys. 2004;58:927–931
- Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: Results of North Central Cancer Treatment Group protocol N0177. Int J Radiat Oncol Biol Phys. 2006;65:1192–1199
- Targeted molecular therapy of malignant gliomas. Curr Neurol Neurosci Rep. 2005;5:186–197
- . Classification of glioblastoma multiforme in adults by molecular genetics. Cancer J. 2003;9:82–90
- The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem. 1997;272:2927–2935
- Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A. 1987;84:6899–6903
- Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci U S A. 1990;87:8602–8606
- Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma. J Neuro Oncol. 2006;8:67–78
- phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol. 2004;22:133–142
- A phase II trial of erlotinib (OSI-774) in patients with recurrent malignant glioma not on EIAEDs. Proc Am Soc Clin Oncol. 2004;22:1502
- Randomized phase II trial of erlotinib (E) versus temozolomide (TMZ) or BCNU in recurrent glioblastoma multiforme (GBM): EORTC 26,034. Proc Am Soc Clin Oncol. 2007;25:2005
- Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma. J Clin Oncol. 2007;25:2288–2294
- Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005;353:2012–2024
- Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J Natl Cancer Inst. 2005;97:880–887
- Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: Tissue analysis from North American Brain Tumor Consortium trials 01-03 and 00-01. Clin Cancer Res. 2005;11:7841–7850
- An update of phase II results from RTOG 0211: A phase I/II study of gefitinib with radiotherapy in newly diagnosed glioblastoma. Proc Am Soc Clin Oncol. 2006;24:1527
- A phase I dose-escalation study of fractionated stereotactic radiosurgery in combination with gefitinib in patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2008;70:993–1001
- Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (Gert)—Phase I/II trial: Study protocol. BMC Cancer. 2006;6:133
- Heimberger Effect of EGFRvIII-targeted vaccine (CDX-110) on immune response and TTP when given with simultaneous standard and continuous temozolomide in patients with GBM. Proc Am Soc Clin Oncol. 2008;26:2011
- Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res. 2000;60:5143–5150
- . Phase I/II study of enzastaurin (ENZ) plus temozolomide (TMZ) and radiation therapy (XRT) in patients with glioblastoma multiforme (GBM) or gliosarcoma (GS). Proc Am Soc Clin Oncol. 2008;26:3559
- Isotype-specific ras (GTP-levels predict the efficacy of farnesyl transferase inhibitors against human astrocytomas regardless of ras mutational status). Cancer Res. 2001;61:4425–4431
- . Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and antiangiogenic effects. Oncogene. 1999;18:7514–7526
- A phase I study of temozolomide and the farnesyltransferase inhibitor, tipifarnib in recurrent glioblastoma: A dose and schedule intensive regimen. J Neurooncol. 2004;6:
- EORTC Study: 26041-22041: Phase I/II study on concomitant and adjuvant zemozolomide (TMZ) and tadiotherapy with or without PTK787/ZK 222584 (PTK/ZK) in newly diagnosed glioblastoma: Results of phase I. Proc Am Soc Clin Oncol. 2007;25:2026
- Antiangiogenic and anti-invasive effects of sunitinib on experimental human glioblastoma. J Neurooncol. 2007;9:412–423
- . Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. J Pharmacol Exp Ther. 2006;319:1070–1080
- A phase II trial of sunitinib in patients with recurrent high-grade glioma. Proc Am Soc Clin Oncol. 2008;26:13001
- A phase I trial of the combination of the antiangiogenic agent sunitinib and radiation therapy for patients with primary and metastatic central nervous system malignancies. J Clin Oncol. 2008;26:2053
- . Vascular integrins in tumor angiogenesis: Mediators and therapeutic targets. Endothelium. 2006;13:113–135
- . Integrin inhibitors reaching the clinic. J Clin Oncol. 2007;25:1637–1638
- Phase I/IIa trial of cilengitide (EMD121974) and temozolomide with concomitant radiotherapy, followed by temozolomide and cilengitide maintenance therapy in patients with newly diagnosed glioblastoma. Proc Am Soc Clin Oncol. 2007;25:2000
- Histone deacetylase inhibitors enhance phosphorylation of histone H2AX after ionizing radiation. Int J Radiat Oncol Biol Phys. 2006;65:859–866
- Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino-methyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells. Int J Cancer. 2004;110:301–308
- Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275. Cancer Res. 2004;64:316–321
- Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid. Int J Cancer. 2005;114:380–386
- Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther. 2006;5:1967–1974
- Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. Clin Cancer Res. 2005;11:4912–4922
- NMDA and AMPA glutamate receptor antagonists in the treatment of human malignant glioma xenografts. Proc Am Assoc Cancer Res. 2004;45:1053–1054
- Fine phase II trial of talampanel in conjunction with standard radiation (RT) and temozolomide (TMZ) in patients with newly diagnosed glioblastoma (GBM). Proc Am Soc Clin Oncol. 2008;26:2014
- . MGMT inhibitors—the Trinity College-Paterson Institute experience, a chemist's perception. DNA Repair (Amst). 2007;6:1161–1169
- Identification of human brain tumour initiating cells. Nature. 2004;432:396–401
- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444:756–760
- Stem cell-related ‘self-renewal' signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. J Clin Oncol. 2008;26:3015–3024
PII: S1053-4296(09)00022-8
doi: 10.1016/j.semradonc.2009.02.005
© 2009 Elsevier Inc. All rights reserved.
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Seminars in Radiation Oncology
Volume 19, Issue 3
, Pages 171-178
, July 2009
