Seminars in Radiation Oncology
Volume 19, Issue 3 , Pages 155-162, July 2009

Functional and Metabolic Magnetic Resonance Imaging and Positron Emission Tomography for Tumor Volume Definition in High-Grade Gliomas

  • Christina I. Tsien, MD

      Affiliations

    • Department of Radiation Oncology, University of Michigan, Ann Arbor, MI
    • Corresponding Author InformationAddress reprint requests to Christina I. Tsien, Department of Radiation Oncology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109
    • ,
  • Yue Cao, PhD

      Affiliations

    • Department of Radiology, University of Michigan, Ann Arbor, MI
    • ,
  • Theodore S. Lawrence, MD, PhD

      Affiliations

    • Department of Radiation Oncology, University of Michigan, Ann Arbor, MI

Although the addition of concurrent and adjuvant temozolomide (TMZ) to standard-dose radiation (60 Gy) improves survival, the pattern of failure continues to be local. Conventional contrast enhanced T1-weighted and T2-weighted magnetic resonance imaging (MRI) used for radiation planning reflect anatomic rather than molecular or functional, properties of the tumor. Functional and metabolic MRI and positron emission tomography are able to detect metabolic and functional abnormalities beyond the tumor volume seen on conventional MRI, assess early response to treatment, and delineate the regions of high risks for failure in high-grade gliomas. This article focuses on the potential of these functional and metabolic imaging techniques to refine our clinical target volumes.

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PII: S1053-4296(09)00020-4

doi:10.1016/j.semradonc.2009.02.002

Seminars in Radiation Oncology
Volume 19, Issue 3 , Pages 155-162, July 2009

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