Seminars in Radiation Oncology
Volume 18, Issue 4 , Pages 265-272 , October 2008

The Implementation of Ablative Hypofractionated Radiotherapy for Stereotactic Treatments in the Brain and Body: Observations on Efficacy and Toxicity in Clinical Practice

  • Lucien A. Nedzi, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Lucien A. Nedzi, MD, Department of Radiation Oncology, UT Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX 75390-9183

References 

  1. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand. 1951;102:316–319
  2. Andersson B, Larsson B, Leksell L, et al. Histopathology of late local radiolesions in the goat brain. Acta Radiol. 1970;9:385–394
  3. Rexed B, Mair W, Sourander P, et al. Effect of high energy protons on the brain of the rabbit. Acta Radiol. 1960;53:289–299
  4. Leksell L. Cerebral radiosurgery I: Gammathalamotomy in two cases of intractable pain. Acta Chir Scand. 1968;134:585–595
  5. Kondziolka D. Functional Radiosurgery Neurosurgery. 1999;44:12–20
  6. Gorgulho AA, De Salles AA. Impact of radiosurgery on the surgical treatment of trigeminal neuralgia. Surg Neurol. 2006;66:350–356
  7. Young RF, Vermulen S, Posewitz A. Gamma knife radiosurgery for the treatment of trigeminal neuralgia. Stereotact Funct Neurosurg. 1998;70(Suppl 1):192–199
  8. Maesawa S, Salame C, Flickinger JC, et al. Clinical outcomes after stereotactic radiosurgery for idiopathic trigeminal neuralgia. J Neurosurg. 2001;94:14–20
  9. Petit JH, Herman JM, Nagda S, et al. Radiosurgical treatment of trigeminal neuralgia: evaluating quality of life and treatment outcomes. Int J Radiat Oncol Biol Phys. 2003;56:1147–1153
  10. Sheehan J, Pan HC, Stroila M, et al. Gamma knife surgery for trigeminal neuralgia: outcomes and prognostic factors. J Neurosurg. 2005;102:434–441
  11. Fountas KN, Smith JR, Lee GP, et al. Gamma Knife stereotactic radiosurgical treatment of idiopathic trigeminal neuralgia: long-term outcome and complications. Neurosurg Focus. 2007;23:E8
  12. Gorgulho AA, De Salles AA. Impact of radiosurgery on the surgical treatment of trigeminal neuralgia. Surg Neurol. 2006;66:350–356
  13. Flickinger JC, Pollock BE, Kondziolka D, et al. Does increased nerve length within the treatment volume improve trigeminal neuralgia radiosurgery? (A prospective double-blind, randomized study). Int J Radiat Oncol Biol Phys. 2001;51:449–454
  14. Massager N, Murata N, Tamura M, et al. Influence of nerve radiation dose in the incidence of trigeminal dysfunction after trigeminal neuralgia radiosurgery. Neurosurgery. 2007;60:681–687
  15. Kondziolka D. Functional Radiosurgery. Neurosurgery. 1999;44:12–20
  16. Young RF, Jacques S, Mark R, et al. Gamma knife thalamotomy for treatment of tremor: Long-term results. J Neurosurg. 2000;93(suppl 3):128–135
  17. Ohye C, Shibazaki T, Sato S. Gamma knife thalamotomy for movement disorders: Evaluation of the thalamic lesion and clinical results. J Neurosurg. 2005;102(suppl):234–240
  18. Romanelli P, Anschel DJ. Radiosurgery for epilepsy. Lancet Neurol. 2006;5:613–620
  19. Gaffey C, Monotoya V, Lyman J, et al. Restriction of the spread of epileptic discharges in cats by mean of Bragg Peak intracranial irradiation. Int J Appl Radiat Isot. 1981;32:779–787
  20. Jenrow KA, Ratkewicz AE, Lemke NW, et al. Effects of kindling and irradiation on neuronal density in the rat dentate gyrus. Neurosci Lett. 2004;371:45–50
  21. Barcio-Salorio JL, Barcia JA, Hernandez G, et al. Radiosurgery of epilepsy: Long-term results. Acta Neurochir suppl (Wein). 1994;62:111–113
  22. Regis J, Rey M, Bartolomei F, et al. Gamma knife surgery in mesial temporal lobe epilepsy: A prospective multicenter study. Epilepsia. 2004;45:504–515
  23. Steiner L, Leksell L, Greitz T, et al. Stereotaxic radiosurgery forcerebral arteriovenous malformations report of a case. Acta Chir Scand. 1972;138:459–464
  24. Karlsson B, Kindquist C, Steiner L. Prediction of Obliteration after Gamma Knife Surgery for Cerebral Arteriovenous Malformations. Neurosurgery. 1997;40:425–431
  25. Flickinger JC, Kondziolka D, Maitz AH, et al. An analysis of the dose-response for arteriovenous malformationradiosurgery and other factors affecting obliteration. Radiotherapy and Oncology. 2002;63:347–354
  26. Liscak R, Vladyka V, Simonova G, et al. Arteriovenous Malformations after Leksell Gamma Knife Radiosurgery: Rate of Obliteration and Complications. Neurosurgery. 2007;60:1005–1016
  27. Maruyama K, Kawahara N, Shin M, et al. The risk of Hemorrhage after Radiosurgery for Cerebral Arteriovenous Malformations. N Engl J Med. 2005;352:146–153
  28. Sinclair J, Chang SD, Gibbs IC, et al. Multisession CyberKnife radiosurgery for intramedullary spinal cord arteriovenous malformations. Neurosurgery. 2006;58:1081–1089
  29. Leksell L. A note on the treatment of acoustinc tumors. Acta Chir Scand. 1971;137:763–765
  30. Linskey ME, Flickinger JC, Lunsford LD. Cranial nerve length predicts the risk of delayed facial and trigeminal neuropathies after acoustic tumour stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 1993;25:227–233
  31. Rowe JG, Radatz MW, Walton L, et al. Clinical experience with gamma knife stereotacticradiosurgery in the management of vestibular schwannomas secondary to type 2 neurofibromatosis. J Neurol Neurosurg Psychiatry. 2003;74:1288–1293
  32. Wowra B, Muacevic A, Jess-Hempen A, et al. Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience. J Neurosurg. 2005;102(Suppl):114–118
  33. Chung WY, Liu KD, Shiau CY, et al. Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases. J Neurosurg. 2005;102(Suppl):87–96
  34. Flickinger JC, Kondziolka D, Niranjan A, et al. Acoustic neuroma radiosurgery with marginal tumor doses of 12 to 13 Gy. Int J Radiat Oncol Biol Phys. 2004;60:225–230
  35. Foote KD, Friedman WA, Buatti JM, et al. Analysis of risk factors associated with radiosurgery for vestibular schwannoma. J Neurosurg. 2001;95:440–449
  36. Weil RS, Cohen JM, Portarena I, et al. Optimal dose of stereotactic radiosurgery for acoustic neuromas: A systematic review. Br J Neurosurg. 2006;20:195–202
  37. Kondziolka D, Lunsford LD, McLaughlin M. Long-term outcomes after radiosurgery for acoustic neuromas. N Engl J Med. 1998;339:1426–1433
  38. Goldsmith BJ. Meningeal tumors. In:  Leibel SA,  Phillips TL editor. Textbook of Radiation Oncology. Philadelphia, PA: Saunders; 2004;p. 497–514
  39. Hakim R, Alexander E, Loeffler J, et al. Results of Linear Accelerator-based Radiosurgery for Intracranial Meningiomas. Neurosurgery. 1998;42:446–454
  40. Kondziolka D, Mathieu D, Lunsford L, et al. Radiosurgery as Definitive Management of Intracranial Meningiomas J. Neurosurgery. 2008;62:53–60
  41. Pollock BE. Stereotactic Radiosurgery for Intracranial Meningiomas: Indications and Results Neurosurg Focus. 2003;14:1–7
  42. Huang D, Halberg FE. Pituitary tumors. In:  Leibel SA,  Phillips TL editor. Textbook of Radiation Oncology. Philadelphia, PA: Saunders; 2004;p. 533–548
  43. Sheehan JP, Niranjan A, Sheehan JM, et al. Stereotactic radiosurgery for pituitary adenomas: An intermediate review of its safety, efficacy, and role in the neurosurgical treatment armamentarium. J Neurosurg. 2005;102:678–691
  44. Tishler RB, Loeffler JS, Lunsford LD, et al. Tolerance of cranial nerves of the cavernous sinus to radiosurgery. Int J Radiat Oncol Biol Phys. 1993;27:215–221
  45. Staford SL, Pollock BE, Leavitt JA, et al. A study on the radiation tolerance of the optic nerves and chiasm after stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2003;55:1177–1181
  46. Blomgren H, Lax I, Näslund I, et al. Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator (Clinical experience of the first thirty-one patients). Acta Oncol. 1995;34:861–870
  47. McGarry RC, Papiez L, Williams M, et al. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: Phase I study. Int J Radiat Oncol Biol Phys. 2005;63:1010–1015
  48. Timmerman R, McGarry R, Yiannoutsos C, et al. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006;24:4833–4839
  49. Koto M, Takai Y, Ogawa Y, et al. A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer. Radiother Oncol. 2007;85:429–434
  50. Sturm V, Kober B, Höver KH, et al. Stereotactic percutaneous single dose irradiation of brain metastases with a linear accelerator. Int J Radiat Oncol Biol Phys. 1987;13:279–282
  51. Kondziolka D, Patel A, Lunsford LD, et al. Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys. 1999;45:427–434
  52. Andrews DW, Scott CB, Sperduto PW, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomised trial. Lancet. 2004;363:1665
  53. Shaw E, Scott C, Souhami L, et al. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: Final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys. 2000;47:291–298
  54. Roos DE, Wirth A, Burmeister BH, et al. Whole brain irradiation following surgery or radiosurgery for solitary brain metastases: Mature results of a prematurely closed randomized (Trans-Tasman Radiation Oncology Group trial (TROG 98.05)). Radiat Oncol. 2006;80:318–322
  55. Aoyama H, Shirato H, Tago M, et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA. 2006;295:2483–2491
  56. Kavanaugh B, Schefter T, Cardenes H, et al. Interim analysis of a prospective phase I/II trial of SBRT for liver metastases. Acta Oncologica. 2006;45:848–855
  57. Hoyer M, Roed H, Hansen A, et al. Phase II study on stereotactic body radiotherapy of colorectal metastases. Acta Oncologica. 2006;45:823–830
  58. Herfarth KK, Debus J, Lohr F, et al. Stereotactic Single-Dose Radiation Therapy of Liver Tumors: Results of a Phase I/II Trial. J Clin Oncol. 2001;19:164–170
  59. Hamilton AJ, Lulu BA, Fosmire H, et al. Preliminary clinical experience with linear accelerator-based spinal stereotactic radiosurgery. Neurosurgery. 1995;36:311–319
  60. Gerszten PC, Burton SA, Ozhasoglu C, et al. Radiosurgery for spinal metastases: Clinical experience in 500 cases from a single institution. Spine. 2007;32:193–199
  61. Ryu S, Jin JY, Jin R, et al. Partial volume tolerance of the spinal cord and complications of single-dose radiosurgery. Cancer. 2007;109:628–636
  62. Ryu S, Jin R, Jin JY, et al. Pain control by image-guided radiosurgery for solitary spinal metastasis. J Pain Symptom Manage. 2008;35:292–298

PII: S1053-4296(08)00038-6

doi: 10.1016/j.semradonc.2008.04.009

Seminars in Radiation Oncology
Volume 18, Issue 4 , Pages 265-272 , October 2008

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