Seminars in Radiation Oncology
Volume 18, Issue 4 , Pages 223-228 , October 2008

Clinical Experience Shows That Catastrophic Late Effects Associated With Ablative Fractionation Can Be Avoided by Technological Innovation

  • Brian Kavanagh, MD, MPH

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Brian Kavanagh, MD, MPH, Department of Radiation Oncology, University of Colorado Denver, Campus Mail Stop F706, 1665 N Ursula St, Suite 1032, PO Box 6510, Aurora, CO 80045

References 

  1. Macbeth FR, Wheldon TE, Girling DJ. Radiation myelopathy: Estimates of risk in 1048 patients in three randomized trials of palliative radiotherapy for non-small cell lung cancer (The Medical Research Council Lung Cancer Working Party). Clin Oncol (R Coll Radiol). 1996;8:176–181
  2. Dische S, Saunders MI. Continuous, hyperfractionated, accelerated radiotherapy (CHART): an interim report upon late morbidity. Radiother Oncol. 1989;16:65–72
  3. Schultheiss TE. Spinal cord radiation “tolerance”: Doctrine vs. data. Int J Radiat Oncol Biol Phys. 1994;30:735–736
  4. Kavanagh BD, Lyckholm L, Sugarman J. Ethics, professional values, and legal considerations in radiation oncology. In:  Perez CA,  Brady LW,  Halperin EC editor. Principles and Practice of Radiation Oncology. (ed 4). Philadelphia, PA: Lippincott Williams & Wilkins; 2004;p. 2461–2470chapter 91
  5. Lovelock DM, Hua C, Wang P. Accurate setup of paraspinal patients using a noninvasive patient immobilization cradle and portal imaging. Med Phys. 2005;32:2606–2614
  6. Ryu S, Jin JY, Jin R. Partial volume tolerance of the spinal cord and complications of single-dose radiosurgery. Cancer. 2007;109:628–636
  7. Chang EL, Shiu AS, Mendel E. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine. 2007;7:151–160
  8. Bijl HP, van Luijk P, Coppes RP. Dose-volume effects in the rat cervical spinal cord after proton irradiation. Int J Radiat Oncol Biol Phys. 2002;52:205–211
  9. Bijl HP, van Luijk P, Coppes RP. Regional differences in radiosensitivity across the rat cervical spinal cord. Int J Radiat Oncol Biol Phys. 2005;61:543–551
  10. Wisnivesky JP, Bonomi M, Henschke C. Radiation therapy for the treatment of unresected stage I-II non-small cell lung cancer. Chest. 2005;128:1461–1467
  11. Darby SC, McGale P, Taylor CW. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: Prospective cohort study of about 300,000 women in US SEER cancer registries. Lancet Oncol. 2005;6:557–565
  12. Roach M, Gandara DR, Yuo HS. Radiation pneumonitis following combined modality therapy for lung cancer: Analysis of prognostic factors. J Clin Oncol. 1995;13:2606–2612
  13. Schneider RA, Schultze J, Jensen JM. 20 years of experience in static intensity-modulated total-body irradiation and lung toxicity: Results in 257 consecutive patients. Strahlenther Onkol. 2007;183:545–551
  14. Carver JR, Shapiro CL, Ng A. American Society of Clinical Oncology clinical evidence review on the ongoing care of adult cancer survivors: Cardiac and pulmonary late effects. J Clin Oncol. 2007;25:3991–4008
  15. McGarry RC, Papiez L, Williams M. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: Phase I study. Int J Radiat Oncol Biol Phys. 2005;63:1010–1015
  16. Yamashita H, Nakagawa K, Nakamura N. Exceptionally high incidence of symptomatic grade 2-5 radiation pneumonitis after stereotactic radiation therapy for lung tumors. Radiat Oncol. 2007;2:21
  17. Timmerman R, McGarry R, Yiannoutsos C. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006;24:4833–4839
  18. Miller KL, Shafman TD, Anscher MS. Bronchial stenosis: An underreported complication of high-dose external beam radiotherapy for lung cancer?. Int J Radiat Oncol Biol Phys. 2005;61:64–69
  19. Kavanagh BD, Ding M, Schefter TE. The dosimetric effect of inhomogeneity correction in dynamic conformal arc stereotactic body radiation therapy for lung tumors. J Appl Clin Med Phys. 2006;7:58–63
  20. Kupelian PA, Willoughby TR, Reddy CA. Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience. Int J Radiat Oncol Biol Phys. 2007;68:1424–1430
  21. Madsen BL, Hsi RA, Pham HT. Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: First clinical trial results. Int J Radiat Oncol Biol Phys. 2007;67:1099–1105
  22. Vargas CE, Martinez AA, Boike TP. High-dose irradiation for prostate cancer via a high-dose-rate brachytherapy boost: Results of a phase I to II study. Int J Radiat Oncol Biol Phys. 2006;66:416–423
  23. Grills IS, Martinez AA, Hollander M. High dose rate brachytherapy as prostate cancer monotherapy reduces toxicity compared to low dose rate palladium seeds. J Urol. 2004;171:1098–1104
  24. Maxon HR, Thomas SR, Hertzberg VS. Relation between effective radiation dose and outcome of radioiodine therapy for thyroid cancer. N Engl J Med. 1983;309:937–941
  25. Li XA, Wang JZ, Stewart RD. Designing equivalent treatment regimens for prostate radiotherapy based on equivalent uniform dose. Br J Radiol. 2008;81:59–68
  26. Coutard H. The conception of periodicity as a possible directing factor in the roentgentherapy of cancer (Twelfth Lewis Linn Mc Arthur Lecture of the Frank Billings Foundation. Delivered before the Institute of Medicine of Chicago and the Chicago Laryngological and Otological Society, October 1, 1935. Cited in Archambeau JO, Slater JM. Skin as a biologic dosimeter). Int J Radiat Oncol Biol Phys. 2004;60:351–352
  27. Edmundson M. Defender of the faith?. New York: Times Magazine; 2007;September 9
  28. Lazaridis N. Sigmund Freud's oral cancer. Br J Oral Maxillofac Surg. 2003;41:78–83

PII: S1053-4296(08)00031-3

doi: 10.1016/j.semradonc.2008.04.002

Seminars in Radiation Oncology
Volume 18, Issue 4 , Pages 223-228 , October 2008