Seminars in Radiation Oncology
Volume 18, Issue 1 , Pages 41-47 , January 2008

Hypofractionation for Prostate Cancer: A Critical Review

  • Edward F. Miles, MD
    • ,
  • W. Robert Lee, MD, MS, Med

      Affiliations

    • Corresponding Author InformationAddress reprint requests to W. Robert Lee, MD, MS, MEd, Department of Radiation Oncology, Duke University School of Medicine, DUMC, Box 3085, Durham, NC 27710.

References 

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  2. Coutard H. Roentgentherapy of epitheliomas of the tonsillar region, hypopharynx, and larynx from 1920 to 1926. AJR Am J Roentgenol. 1932;28:313–331
  3. Fowler JF, Ritter MA, Chappell RJ. What hypofractionated protocols should be tested for prostate cancer?. Int J Radiat Oncol Biol Phys. 2003;56:1093–1104
  4. Fowler JF. The radiobiology of prostate cancer including new aspects of fractionated radiotherapy. Acta Oncol. 2005;44:265–276
  5. Brenner DJ, Hall EJ. Fractionation and protraction for radiotherapy of prostate carcinoma. Int J Radiat Oncol Biol Phys. 1999;43:1095–1101
  6. Brenner DJ, Martinez AA, Edmundson GK. Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue. Int J Radiat Oncol Biol Phys. 2002;52:6–13
  7. D’Amico AV, Whittington R, Malkowicz SB. Pretreatment nomogram for prostate-specific antigen recurrence after radical prostatectomy or external-beam radiation therapy for clinically localized prostate cancer. J Clin Oncol. 1999;17:168–172
  8. Collins CD. Radical external beam radiotherapy for localized carcinoma of the prostate using a hypofractionation technique. Clin Oncol (R Coll Radiol). 1991;3:358;(letter)
  9. Livsey JE, Cowan RA, Wylie JP. Hypofractionated conformal radiotherapy in carcinoma of the prostate: Five-year outcome analysis. Int J Radiat Oncol Biol Phys. 2003;57:1254–1259
  10. Consensus statement: Guidelines for PSA following radiation therapy (American Society for Therapeutic Radiology and Oncology Consensus Panel). Int J Radiat Oncol Biol Phys. 1997;37:1035–1041
  11. Kupelian PA, Reddy CA, Klein EA. Short-course intensity-modulated radiotherapy (70 GY at 2.5 GY per fraction) for localized prostate cancer: preliminary results on late toxicity and quality of life. Int J Radiat Oncol Biol Phys. 2001;51:988–993
  12. Kupelian PA, Willoughby TR, Reddy CA. Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Cleveland Clinic experience. Int J Radiat Oncol Biol Phys. 2007;63:1424–1430
  13. Tsuji H, Yanagi T, Ishikawa H. Hypofractionated radiotherapy with carbon ions for prostate cancer. Int J Radiat Oncol Biol Phys. 2005;63:1153–1160
  14. Soete G, Arcangeli S, De Meerleer G. Phase II study of a four-week hypofractionated external beam radiotherapy regimen for prostate cancer: report on acute toxicity. Radiother Oncol. 2006;80:78–81
  15. Martin JM, Bayley A, Bristow R. A prospective study of hypofractionated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2006;66:S35–S36
  16. Ritter MA, Forman JD, Petereit DG. Dose-per-fraction escalation for localized prostate cancer: A multi-institutional phase I/II Trial. Int J Radiat Oncol Biol Phys. 2006;66:S11;(abstr)
  17. Madsen BL, His RA, Pham HT. Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.4 Gy in five fractions for localized disease: First clinical trial results. Int J Radiat Oncol Biol Phys. 2007;67:1099–1105
  18. Lukka H, Hayter C, Warde P. A randomized trial comparing two fractionation schedules for patients with localized prostate cancer. Int J Radiat Oncol Biol Phys. 2003;57(suppl):S126;(abstr)
  19. Yeoh EE, Fraser RJ, McGowan RE. Evidence for efficacy without increased toxicity of hypofractionated radiotherapy for prostate carcinoma: Early results of a phase III randomized trial. Int J Radiat Oncol Biol Phys. 2003;55:943–955
  20. Pollack A, Hanlon AL, Horwitz EM. Dosimetry and preliminary acute toxicity in the first 100 men treated for prostate cancer on a randomized hypofractionation dose escalation trial. Int J Radiat Oncol Biol Phys. 2006;64:518–526
  21. Dearnaley DP, Syndikus I, Norman AR. In: Conventional or hypofractionated high dose intensity modulated radiotherapy in prostate cancer: Preliminary report on acute and late toxicity. The Prostate Cancer Symposium: A Multidisciplinary Approach, Orlando, FL, February 22–24. 2007;
  22. Roach M, Hanks G, Thames H. Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys. 2006;65:965–974

PII: S1053-4296(07)00078-1

doi: 10.1016/j.semradonc.2007.09.006

Seminars in Radiation Oncology
Volume 18, Issue 1 , Pages 41-47 , January 2008

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