Seminars in Radiation Oncology
Volume 17, Issue 2 , Pages 89-98, April 2007

Using Biological Markers to Predict Risk of Radiation Injury

  • Katharina Fleckenstein, MD

      Affiliations

    • Department of Radiation Oncology, Duke University Medical Center, Durham NC.
    • Department of Radiation Oncology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany.
    • ,
  • Benjamin Gauter-Fleckenstein, MD

      Affiliations

    • Department of Radiation Oncology, Duke University Medical Center, Durham NC.
    • Department of Anaesthesiology, Mannheim Medical Center, University of Heidelberg, Mannheim, Germany.
    • ,
  • Isabel L. Jackson, BS

      Affiliations

    • Department of Radiation Oncology, Duke University Medical Center, Durham NC.
    • ,
  • Zahid Rabbani, MD

      Affiliations

    • Department of Radiation Oncology, Duke University Medical Center, Durham NC.
    • ,
  • Mitchell Anscher, MD

      Affiliations

    • Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA.
    • ,
  • Zeljko Vujaskovic, MD, PhD

      Affiliations

    • Department of Radiation Oncology, Duke University Medical Center, Durham NC.
    • Corresponding Author InformationAddress reprint requests to Zeljko Vujaskovic, MD, PhD, Department of Radiation Oncology, DUMC, Box 3455, Durham, NC 27710.

Recent advances in our understanding of the molecular events leading to the development of normal tissue complications after radiotherapy has led to an effort to identify biological markers that could identify patients at increased or decreased risk for treatment related injury. The goal of this effort is to improve the therapeutic ratio and enable physicians to optimize therapy for individual patients. In radiotherapy of the thoracic region, the lung is one of the most critical dose-limiting organs. This review briefly introduces the mechanisms of radiation-induced lung injury and gives a summary of clinical research focused on evaluating changes in biological markers before, during, and after radiation therapy of the thorax.

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 Supported in part by the DFG (German Research Society), Research Fellowship Grant for Katharina Fleckenstein (FL551/1-1) and by the NIH, RO1 # CA 098452 (PI: Zeljko Vujaskovic).

PII: S1053-4296(06)00105-6

doi:10.1016/j.semradonc.2006.11.004

Seminars in Radiation Oncology
Volume 17, Issue 2 , Pages 89-98, April 2007

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