Seminars in Radiation Oncology
Volume 17, Issue 1 , Pages 45-52 , January 2007

Preoperative Chemoradiation for the Treatment of Locoregional Esophageal Cancer: The Standard of Care?

  • Bryan J. Schneider, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Bryan J. Schneider, MD, C361 Med Inn Bldg., 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0848.
    • ,
  • Susan G. Urba, MD

References 

  1. Jemal A, Murray T, Ward E. Cancer statistics, 2005. CA Cancer J Clin. 2005;55:10–30
  2. Kasai M, Mori S, Watanabe T. Follow up results after resections of thoracic esophageal cancer. World J Surg. 1978;2:543–551
  3. Earlan F, Cunha-Mejo R. Oesophageal squamous cell carcinoma: A critical review of surgery. Br J Surg. 1980;67:381–390
  4. Orringer MB. Transhiatal esophagectomy without thoracotomy for carcinoma of the thoracic esophagus. Ann Surg. 1984;200:282–288
  5. Orringer MB, Marshall B, Iannettoni MD. Transhiatal esophagectomy: Clinical experience and refinements. Ann Surg. 1999;230:392–400
  6. Walsh TN, Noonan N, Hollywood D. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med. 1996;335:462–467
  7. Apinop C, Puttisak P, Preecha N. A prospective study of combined therapy in esophageal cancer. Hepatogastroenterology. 1994;41:391–393
  8. Nygaard K, Hagen S, Hansen HS The second Scandinavian trial in esophageal cancer. Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma: A randomized, multicenter study of pre-operative radiotherapy and chemotherapy. World J Surg. 1992;16:1104–1110
  9. Urba S, Orringer M, Turrisi . A randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol. 2001;19:305–313
  10. Bosset JF, Gignoux M, Triboulet JP. Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med. 1997;337:161–167
  11. Burmeister BH, Smithers BM, Gebski V. Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: A randomized controlled phase III trial. Lancet Oncol. 2005;6:659–668
  12. Le Prise E, Etienne PL, Meunier B. A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous cell carcinoma of the esophagus. Cancer. 1994;73:1779–1784
  13. Medical Research Council Oesophageal Cancer Working Party. Surgical resection with or without preoperative chemotherapy in oesophageal cancer: A randomized controlled trial. Lancet. 2002;359:1727–1733
  14. Kok TC, van Lanschot J, Siersma PD. Neo-adjuvant chemotherapy in operable esophageal squamous cell cancer: Final report of a phase III multicenter randomized trial. Proc Am Soc Oncol. 1997;16:227;(abstr)
  15. Kelsen DP, Ginsberg R, Pajak TF. Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med. 1998;339:1979–1984
  16. Law SMB, Fok M, Chow S. Preoperative chemotherapy versus surgical therapy alone for squamous cell carcinoma of the esophagus: A prospective randomized trial. J Thorac Cardovasc Surg. 1997;114:210–217
  17. Ancona E, Ruol A, Santi S. Only pathologic complete response to neo-adjuvant chemotherapy improves significantly the long term survival of patients with resectable esophageal squamous cell carcinoma. Cancer. 2001;91:2165–2174
  18. Cunningham D, Allum WH, Stenning SP. Perioperative chemotherapy in operable gastric and lower oesophageal cancer: Final results of a randomized, controlled trial (the MAGIC trial, ISRCTN 93793971). Proc Am Soc Oncol. 2005;23:16s;(abstr 4001)
  19. Launois B, Delarue D, Campion JP. Preoperative radiotherapy for carcinoma of the esophagus. Surg Gynecol Obstet. 1981;153:690–692
  20. Paillot B. The value of preoperative radiotherapy in esophageal cancer: Results of a study of the E.O.R.T.C. Gignoux M Roussel A World J Surg. 1987;11:426–432
  21. Huang GJ, Gu XZ, Wang LJ. Experience with combined preoperative irradiation and surgery for carcinoma of the esophagus. Gan Monogr Cancer Res. 1986;31:159–164
  22. Arnott SJ, Duncan W, Gignoux M. Preoperative Radiotherapy in esophageal carcinoma: a meta-analysis using individual patient data (oesophageal cancer collaborative group). Int J Radiat Oncol Biol Phys. 1998;41:579–583
  23. Krasna M, Tepper JE, Niedzwiecki D. Trimodality therapy is superior to surgery alone in esophageal cancer: Results of CALGB 9781. 2006;Presened at the 3rd annual American Society of Clinical Oncology Gastrointestinal Cancers Symposium. San Francisco, CA, January 26-28
  24. Urschel JD, Vasan HB. A meta-analysis of randomized controlled trials that compared neo-adjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer. Am J Surg. 2003;185:538–543
  25. Fiorica F, Di Bona D, Schepis F. Preoperative chemoradiotherapy for oesophageal cancer: A systemic review and meta-analysis. Gut. 2004;53:925–930
  26. MacDonald JS, Smalley SR, Benedetti J. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345:725–730
  27. Bedenne L, Michel P, Bouche O. Randomized phase III trial in locally advanced esophageal cancer: Radiochemotherapy followed by surgery versus radiochemotherapy alone (FFCD 9102). Proc Am Soc Clin Oncol. 2002;21:519;(abstr)
  28. Stahl M, Stuschke M, Lehmann N. Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol. 2005;23:2310–2317
  29. Vogel SB, Mendenhall WM, Sombeck MD. Downstaging of esophageal cancer after preoperative radiation and chemotherapy. Ann Surg. 1995;221:685–695
  30. Triboulet JP, Amrouni H, Guillem P. Devenir des cancers epidermoides de l’oesophage en responsif complète après chimioradiotherapie pre-operatoire. Ann Chir. 1998;52:503–508
  31. Forastiere AA, Heitmiller RF, Kleinberg GL. Multimodality therapy for esophageal cancer. Chest. 1997;112:195S–200S
  32. Berger AC, Farma J, Scott WJ. Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival. J Clin Oncol. 2005;23:4330–4337
  33. Urba SG, Orringer MB, Ianettonni M. Concurrent cisplatin, paclitaxel and radiotherapy as preoperative treatment for patients with locoregional esophageal carcinoma. Cancer. 2003;98:2177–2183
  34. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology, v. 1.2006. Esophageal Cancer, http://www.nccn.org/professionals/physician_gls/PDF/esophagel.pdf (accessed 11/6/06).

PII: S1053-4296(06)00067-1

doi: 10.1016/j.semradonc.2006.09.002

Seminars in Radiation Oncology
Volume 17, Issue 1 , Pages 45-52 , January 2007

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