Seminars in Radiation Oncology
Volume 16, Issue 4 , Pages 249-259 , October 2006

Radiation Therapy With Charged Particles

  • Daniela Schulz-Ertner, MD

      Affiliations

    • Department of Radiation Oncology, University of Heidelberg, Germany.
  • ,
  • Oliver Jäkel, PhD

      Affiliations

    • Department of Medical Physics in Radiation Oncology, Deutsches Krebsforschungszentrum, Germany.
  • ,
  • Wolfgang Schlegel, PhD

      Affiliations

    • Department of Medical Physics in Radiation Oncology, Deutsches Krebsforschungszentrum, Germany.
    • Corresponding Author InformationAddress reprint requests to Wolfgang Schlegel, PhD, Deutsches Krebsforschungszentrum (dkfz), Abteilung Medizinische Physik in der Strahlentherapie (E040), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

References 

  1. Wilson RR . Radiological use of fast protons . Radiology . 1946;47:487–491
  2. Castro JR , Linstadt DE , Bahary J-P . Experience in charged particle irradiation of tumors of the skull base 1977-1992 . Int J Radiat Oncol Biol Phys . 1994;29:647–655
  3. Castro JR . Clinical programs: A review of past and existing hadron protocols . In:  Amaldi U ,  Larrson B ,  Lemoigne Y editor. Advances in Hadron Therapy . Amsterdam, The Netherlands: Elsevier Science; 1997;p. 79–94
  4. Jäkel O , Schulz-Ertner D , Karger C . Heavy ion therapy: status and perspectives . Technol Cancer Res Treat . 2003;2:377–388
  5. Sisterson JM: Particles Newsletter, Available at: http://ptcog.mgh.harvard.edu/. Accessed 5/31/2006
  6. Mandrillon P . Pros and cons of various accelerator types . In:  Linz U editors. Ion Beams in Tumour Therapy . Weinheim, Germany: Chapman and Hall; 1995;p. 181–190
  7. Pedroni E . Concepts for gantry systems . In:  Linz U editors. Ion Beams in Tumour Therapy . Weinheim, Germany: Chapman and Hall; 1995;p. 213–233
  8. Eickhoff H , Haberer T , Kraft G . The GSI cancer therapy project . Strahlenther Onkol . 1999;175(suppl 2):21–24
  9. Schlegel W , Pastyr O , Bortfeld T . Computer systems and mechanical tools for stereotactically guided conformation therapy with linear accelerators . Int J Radiat Oncol Biol Phys . 1992;24:781–787
  10. Minohara S , Kanai T , Endo M . Respiratory gated irradiation system for heavy-ion radiotherapy . Int J Radiat Oncol Biol Phys . 2000;47:1097–1103
  11. Jäkel O , Jacob C , Schardt D . Relation between carbon ions ranges and X-ray CT numbers . Med Phys . 2001;28:701–703
  12. Paganetti H , Bortfeld T . Proton therapy . In:  Schlegel W ,  Bortfeld T ,  Grosu AL editor. New Technologies in Radiation Oncology . New York, NY: Springer; 2005;p. 345–363
  13. Scholz M , Kellerer AM , Kraft-Weyrather W . Computation of cell survival in heavy ion beams for therapy—The model and its approximation . Radiat Environ Biophys . 1997;36:59–66
  14. Paganetti H , Goitein M . Radiobiological significance of beam line dependent proton energy distributions in a spread-out Bragg peak . Med Phys . 2000;27:1119–1126
  15. Kanai T , Endo M , Minohara S . Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy . Int J Radiat Oncol Biol Phys . 1999;44:201–210
  16. Krämer M , Scholz M . Treatment planning for heavy ion radiotherapy: Calculation and optimization of biologically effective dose . Phys Med Biol . 2000;45:3319–3330
  17. Jäkel O , Krämer M , Karger CP . Treatment planning for heavy ion radio-therapy: Clinical implementation and application . Phys Med Biol . 1999;46:1101–1116
  18. Fuss M , Hug EB , Schaefer RA . Proton radiation therapy (PRT) for pediatric optic pathway gliomas: Comparison with 3D planned conventional photons and a standard photon technique . Int J Radiat Oncol Biol Phys . 1999;45:1117–1126
  19. Lee CT , Bilton SD , Famiglietti RM . Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: How do protons compare with other conformal techniques? . Int J Radiat Oncol Biol Phys . 2005;63:362–372
  20. Yock T , Schneider R , Friedmann A . Proton radiotherapy for orbital rhabdomyosarcoma: Clinical outcome and a dosimetric comparison with photons . Int J Radiat Oncol Biol Phys . 2005;63:1161–1168
  21. Miralbell R , Celia L , Weber D . Optimizing radiotherapy of orbital and paraorbital tumors: Intensity-modulated x-ray beams vs (intensity-modulated proton beams) . Int J Radiat Oncol Biol Phys . 2000;47:1111–1119
  22. Egger E , Zografos L , Schalenbourg A . Eye retention after proton beam radiotherapy for uveal melanoma . Int J Radiat Oncol Biol Phys . 2003;55:867–880
  23. Munzenrider JE , Liebsch NJ . Proton therapy for tumors of the skull base . Strahlenther Onkol . 1999;175(suppl 2):57–63
  24. Bush DA , Slater JD , Shin BB . Hypofractionated proton beam radiotherapy for stage I lung cancer . Chest . 2004;126:1198–1203
  25. Wulf J , Hädinger U , Oppitz U . Stereotactic radiotherapy of targets in the lung and liver . Strahlenther Onkol . 2001;177:645–655
  26. Hof H , Herfarth KK , Münter M . Stereotactic single-dose radiotherapy of stage I non-small-cell lung cancer (NSCLC) . Int J Radiat Oncol Biol Phys . 2003;56:335–341
  27. Slater JD , Yonemoto LT , Rossi CJ . Conformal proton therapy for prostate carcinoma . Int J Radiat Oncol Biol Phys . 1998;42:299–304
  28. Zelefsky MJ , Fuks Z , Hunt M . High-dose intensity modulated radiation therapy for prostate cancer: Early toxicity and biochemical outcome in 772 patients . Int J Radiat Oncol Biol Phys . 2002;53:1111–1116
  29. Kraft G . RBE and its interpretation . Strahlenther Onkol . 1999;175(suppl 2):44–47
  30. Catton C , O’Sullivan B , Bell R . Chordoma: Long-term follow-up after radical photon irradiation . Radiother Oncol . 1996;41:67–72
  31. Romero J , Cardenes H , la Torre A . Chordoma: Results of radiation therapy in eighteen patients . Radiother Oncol . 1993;29:27–32
  32. Debus J , Schulz-Ertner D , Schad L . Stereotactic fractionated radiotherapy for chordomas and chondrosarcomas of the skull base . Int J Radiat Oncol Biol Phys . 2000;47:591–596
  33. Hug EB , Loredo LN , Slater JD . Proton radiation therapy for chordomas and chondrosarcomas of the skull base . J Neurosurg . 1999;91:432–439
  34. Noel G , Habrand JL , Jauffret E . Radiation therapy for chordoma and chondrosarcoma of the skull base and the cervical spine (Prognostic factors and pattern of failure) . Strahlenther Onkol . 2003;179:241–248
  35. Schulz-Ertner D , Nikoghosyan A , Thilmann C . Results of carbon ion RT in 152 patients . Int J Radiat Oncol Biol Phys . 2004;58:631–640
  36. Schulz-Ertner D , Haberer T , Jäkel O . Acute radiation-induced toxicity of heavy ion radiotherapy delivered with intensity modulated pencil beam scanning in patients with base of skull tumors . Radiother Oncol . 2002;64:189–195
  37. Mizoe J , Tsujii H , Kamada T . Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer . Int J Radiat Oncol Biol Phys . 2004;60:358–364
  38. Batterman JJ , Breur K , Hart GA . Observations on pulmonary metastases in patients after single doses and multiple fractions of fast neutrons and cobalt-60 gamma rays . Eur J Cancer . 1981;17:539–548
  39. Laramore GE , Krall JM , Griffin TW . Neutron versus photon irradiation for unresectable salivary gland tumors: Final report of an RTOG-MRC randomized clinical trial . Int J Radiat Oncol Biol Phys . 1993;27:235–240
  40. Schulz-Ertner D , Nikoghosyan A , Didinger B . Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques . Cancer . 2005;104:338–344
  41. Minohara S , Endo M , Kanai T . Estimating uncertainties of the geometrical range of particle radiotherapy during respiration . Int J Radiation Oncology Biol Phys . 2003;56:121–125
  42. Miyamoto T , Yamamoto N , Nishimura H . Carbon ion radiotherapy for stage I non-small cell lung cancer . Radiother Oncol . 2003;66:127–140
  43. Tsujii H , Mizoe J , Kamada T . Overview of clinical experiences on carbon ion radiotherapy at NIRS . Radiother Oncol . 2004;73:41–49
  44. Herfarth KK , Debus J , Lohr F . Stereotactic single-dose radiation therapy of liver tumors: Results of a phase I/II trial . J Clin Oncol . 2001;19:164–170
  45. Herfarth KK , Hof H , Bahner ML . Assessment of focal liver reaction by multiphasic CT after stereotactic single-dose radiotherapy of liver tumors . Int J Radiat Oncol Biol Phys . 2003;57:444–451
  46. Kato H , Tsujii H , Miyamoto T . Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis . Int J Radiat Oncol Biol Phys . 2004;59:1468–1476
  47. Catton CN , O’Sullivan B , Kotwall C . Outcome and prognosis in retroperitoneal soft tissue sarcoma . Int J Radiat Oncol Biol Phys . 1994;29:1005–1010
  48. Hug EB , Fitzek MM , Liebsch NJ . Locally challenging osteo- and chondrogenic tumors of the axial skeleton: Results of combined proton and photon radiation therapy using three-dimensional treatment planning . Int J Radiat Oncol Biol Phys . 1995;31:467–476
  49. Schoenthaler R , Castro JR , Petti P . Charged particle irradiation of sacral chordomas . Int J Radiat Oncol Biol Phys . 1993;26:291–298
  50. Kamada T , Tsujii H , Tsuji H . Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas . J Clin Oncol . 2002;20:4466–4471
  51. Imai R , Kamada T , Tsujii H . Carbon ion radiotherapy for unresectable sacral chordomas . Clin Cancer Res . 2004;10:5741–5746
  52. Karger CP , Jäkel O , Debus J . Three-dimensional accuracy and interfractional reproducibility of patient fixation using a stereotactic head mask system . Int J Radiat Oncol Biol Phys . 2001;49:1223–1234
  53. Hanks GE , Hanlon AL , Pinover WH . Dose escalation for prostate cancer patients based on dose comparison and dose response studies . Int J Radiat Oncol Biol Phys . 2000;46:823–832
  54. Fowler J , Chappell R , Ritter M . Is α/β for prostate tumors really low? . Int J RAdiat Oncol Biol Phys . 2001;50:1021–1031
  55. Nikoghosyan A , Schulz-Ertner D , Didinger B . Evaluation of the therapeutical potential of heavy ion therapy for patients with locally advanced prostate cancer . Int J Radiat Oncol Biol Phys . 2004;58:89–97
  56. Akakura K , Tsujii H , Morita S . Phase I/II clinical trials of carbon ion therapy for prostate cancer . Prostate . 2004;58:252–258
  57. Tsujii H , Yanagi T , Ishikawa H . Hypofractionated radiotherapy with carbon ion beams for prostate cancer . Int J Radiat Oncol Biol Phys . 2005;63:1153–1160

PII: S1053-4296(06)00034-8

doi: 10.1016/j.semradonc.2006.04.008

Seminars in Radiation Oncology
Volume 16, Issue 4 , Pages 249-259 , October 2006