Seminars in Radiation Oncology
Volume 16, Issue 3 , Pages 168-176 , July 2006

Integrating Radiation Into the Management of Vulvar Cancer

  • Elizabeth A. Barnes, MD, FRCP(C)

      Affiliations

    • Department of Radiation Oncology,University of Toronto, Toronto, Ontario, Canada
    • Corresponding Author InformationAddress reprint requests to Elizabeth A. Barnes, MD, FRCP(C), Toronto Sunnybrook Regional Cancer Center, 2075 Bayview Ave, Toronto, Ontario, Canada, M4N 3M5.
    • ,
  • Gillian Thomas, MD, FRCP(C)

      Affiliations

    • Department of Radiation Oncology,University of Toronto, Toronto, Ontario, Canada
    • Department of Obstetrics and Gynecology,University of Toronto, Toronto, Ontario, Canada.

References 

  1. Way S . The anatomy of the lymphatic drainage of the vulva and its influence on the radical operation . Ann R Coll Surg Engl . 1948;3:1159–1164
  2. Taussig FJ . Cancer of the vulva (An analysis of 155 cases (1911-1940)) . Am J Obstet Gynecol . 1949;40:764–769
  3. Hacker NF , Berek JS , Juillard GJF , et al.   Preoperative radiation therapy for locally advanced vulvar cancer . Cancer . 1984;54:2056–2061
  4. Stehman FB , Bundy BN , Ball H , et al.   Sites of failure and times to failure in carcinoma of the vulva treated conservatively (A Gynecologic Oncology Group study) . Am J Obstet Gynecol . 1996;174:1128–1132
  5. Homesley HD , Bundy BN , Sedlis A , et al.   Prognostic factors for groin node metastasis in squamous cell carcinoma of the vulva (a Gynecologic Oncology Group study) . Gynecol Oncol . 1993;49:279–283
  6. Petereit DG , Mehta MP , Buchler DA , et al.   Inguinofemoral radiation of N0,N1 vulvar cancer may be equivalent to lymphadenectomy if proper radiation technique is used . Int J Radiat Oncol Biol Phys . 1993;27:963–967
  7. Thomas GM , Dembo AJ , Bryson SCP , et al.   Changing concepts in the management of vulvar cancer . Gynecol Oncol . 1991;42:9–21
  8. Homesley HD , Bundy BN , Sedlis A , et al.   Radiation therapy versus pelvic node resection for carcinoma of the vulva with positive groin nodes . Obstet Gynecol . 1986;68:733–740
  9. Origoni M , Sideri M , Garsia S , et al.   Prognostic value of pathological patterns of lymph node positivity in squamous cell carcinoma of the vulva stage III and IVA FIGO . Gynecol Oncol . 1992;45:313–316
  10. van der Velden J , van Lindert AC , Lammes FB , et al.   Extracapsular growth of lymph node metastases in squamous cell carcinoma of the vulva. The impact on recurrence and survival . Cancer . 1995;75:2885–2890
  11. Paladini D , Cross P , Lopes A , Monaghan JM . Prognostic significance of lymph node variables in squamous cell carcinoma of the vulva . Cancer . 1994;74:2491–2496
  12. Katz A , Eifel PJ , Jhingran A , et al.   The role of radiation therapy in preventing regional recurrences of invasive squamous cell carcinoma of the vulva . Int J Radiat Oncol Biol Phys . 2003;57:409–418
  13. DiSaia PJ . What is the proper extent of an inguinal lymphadenectomy for early vulvar cancer? . Gynecol Oncol . 2003;90:687–688
  14. de Hullu JA , Hollema H , Piers DA , et al.   Sentinel lymph node procedure is highly accurate in squamous cell carcinoma of the vulva . J Clin Oncol . 2000;18:2811–2816
  15. Stehman FB , Bundy BN , Thomas G , et al.   Groin dissection versus groin radiation in carcinoma of the vulva (A Gynecologic Oncology Group study) . Int J Radiat Oncol Biol Phys . 1992;24:389–396
  16. Koh WJ , Chiu M , Stelzer KJ , et al.   Femoral vessel depth and the implications for groin node radiation . Int J Radiat Oncol Biol Phys . 1993;27:969–974
  17. Manavi M , Berger A , Kucera E , et al.   Does T1, N0-1 vulvar cancer treated by vulvectomy but not lymphadenectomy need inguinofemoral radiation? . Int J Radiat Oncol Biol Phys . 1997;38:749–753
  18. Montana GS , Thomas GM , Moore DH , et al.   Preoperative chemo-radiation for carcinoma of the vulva with N2/N3 nodes (A gynecologic oncology group study) . Int J Radiat Oncol Biol Phys . 2000;48:1007–1013
  19. Thomas G , Dembo A , DePetrillo A , et al.   Concurrent radiation and chemotherapy in vulvar carcinoma . Gynecol Oncol . 1989;34:263–267
  20. Chao KSC , Lin BS . Lymphangiogram-assisted lymph node target delineation for patients with gynecologic malignancies . Int J Radiat Oncol Biol Phys . 2002;54:1147–1152
  21. Grigsby PW , Roberts HL , Perez CA . Femoral neck fracture following groin irradiation . Int J Radiat Oncol Biol Phys . 1995;32:63–67
  22. Hacker NF , Leuchter RS , Berek JS , et al.   Radical vulvectomy and bilateral inguinal lymphadenectomy through separate groin incisions . Obstet Gynecol . 1981;58:574–579
  23. Burke TW , Stringer CA , Gershenson DM , et al.   Radical wide excision and selective inguinal node dissection for squamous cell carcinoma of the vulva . Gynecol Oncol . 1990;38:328–332
  24. Heaps JM , Fu YS , Montz FJ , et al.   Surgical-pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva . Gynecol Oncol . 1990;38:309–314
  25. Faul CM , Mirmow D , Huang Q , et al.   Adjuvant radiation for vulvar carcinoma (Improved local control) . Int J Radiat Oncol Biol Phys . 1997;38:381–389
  26. Acosta AA , Given FT , Frazier AB , et al.   Preoperative radiation therapy in the management of squamous cell carcinoma of the vulva (Preliminary report) . Am J Obstet Gynecol . 1978;132:198–206
  27. Moore DH , Thomas GM , Montana GS , et al.   Preoperative chemoradiation for advanced vulvar cancer (A phase II study of the Gynecologic Oncology Group) . Int J Radiat Oncol Biol Phys . 1998;42:79–85
  28. Cunningham MJ , Goyer RP , Gibbons SK , et al.   Primary radiation, cisplatin, and 5-fluorouracil for advanced squamous carcinoma of the vulva . Gynecol Oncol . 1997;66:258–261
  29. Erickson B , Gillin MT . Interstitial implantation of gynecologic malignancies . J Surg Oncol . 1997;66:285–295
  30. Janda M , Obermair A , Cella D , et al.   Vulvar cancer patients’ quality of life (A qualitative assessment) . Int J Gynecol Cancer . 2004;14:875–881
  31. Mansoor R: NSGO-CC-0301: A phase II study of management of the patients with locally advanced (FIGO III & IVa or stage II unfavorably located lesion) or relapsed vulvar carcinoma.

PII: S1053-4296(06)00007-5

doi: 10.1016/j.semradonc.2006.02.006

Seminars in Radiation Oncology
Volume 16, Issue 3 , Pages 168-176 , July 2006

Article Tools

* Image Usage & Resolution