Seminars in Radiation Oncology
Volume 16, Issue 3 , Pages 138-143 , July 2006

Intensity-Modulated Radiation Therapy for Gynecologic Cancers: Pitfalls, Hazards, and Cautions To Be Considered

  • Marcus E. Randall, MD, FACR

      Affiliations

    • Leo W. Jenkins Cancer Center and Brody School of Medicine, East Carolina University, Greenville, NC.
    • Corresponding Author InformationAddress reprint requests to Marcus E. Randall, MD, FACR, Department of Radiation Oncology, Leo W. Jenkins Cancer Center, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, NC 27834.
  • ,
  • Geoffrey S. Ibbott, PhD, FACR, FAAPM

      Affiliations

    • Radiological Physics Center, UT M. D. Anderson Cancer Center, Houston, TX

References 

  1. Mundt AJ , Roeske JC . Can intensity-modulated radiation therapy replace brachytherapy in the management of cervical cancer? . Counterpoint. Brachytherapy . 2002;1:192–194
  2. Sternick ES . The Theory and Practice of Intensity Modulated Radiation Therapy . Madison, WI: Advanced Medical Publishing; 1997;
  3. NCI Guidelines for the Use of IMRT in Clinical Trials. Letter from NCI dated January 14, 2005.
  4. Molineu A , Followill D , Balter P , et al.   Design and implementation of an anthropomorphic quality assurance phantom for intensity-modulated radiation therapy for the Radiation Therapy Oncology Group . Int J Radiat Oncol Biol Phys . 2005;63:577–583
  5. Intensity Modulated Radiation Therapy Collaborative Working Group . Intensity-modulated radiotherapy. Current status and issues of interest . Int J Radiat Oncol Biol Phys . 2001;51:880–914
  6. Galvin JM , Ezzell G , Eisbrauch A , et al.   Implementing IMRT in clinical practice (A joint document of the American Society for Therapeutic Radiology and Oncology and the American Association of Physicists in Medicine) . Int J Radiat Oncol Biol Phys . 2004;58:1616–1634
  7. Ezzell GA , Galvin JM , Low DA , et al.   Guidance document on delivery, treatment planning, and clinical implementation of IMRT (Report of the IMRT Subcommittee of the AAPM Radiation Therapy Committee) . Med Phys . 2003;30:2089–2115
  8. Luxton RW , Kunkler PB . Radiation nephritis . Acta Radiol Therap Phys Biol . 1964;2:169–178
  9. Glatstein E . The return of the snake oil salesmen . Int J Radiat Oncol Biol Phys . 2003;55:561–562
  10. Glatstein E . Intensity modulated radiation therapy (The inverse, the converse, and the perverse) . Semin Radiat Oncol . 2002;12:272–281
  11. Kagan AR , Schulz RJ . Intensity-modulated radiotherapy for adenocarcinoma of the prostate (A point of view) . Int J Radiat Oncol Biol Phys . 2005;62:454–459
  12. Cohan RH , Ellis JH , Garner WL . Extravasation of radiographic contrast material (Recognition, prevention, and treatment) . Radiology . 1996;200:593–604
  13. Khoo VS , Oldham M , Adams EJ , et al.   Comparison of intensity-modulated tomotherapy with stereotactically guided conformal radiotherapy for brain tumors . Int J Radiat Oncol Biol Phys . 1999;45:415–425
  14. Dorr W , Herrmann T . Second primary tumors after radiotherapy for malignancies . Treatment-related parameters. Strahlenth und Onk . 2002;178:357–362
  15. Mundt AJ , Lujan AE , Rotmensch J . Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies . Int J Radiat Oncol Biol Phys . 2002;52:1330–1337
  16. Camilien L , Fordon D , Fruchter RG . Predictive value of computerized tomography in the presurgical evaluation of primary carcinoma of the cervix . Gynecol Oncol . 1988;30:209–215
  17. Langer MP , Papiez L , Spirydovich S , et al.   The need for rotational margins in intensity-modulated radiotherapy and a new method for planning target volume design . Int J Radiat Oncol Biol Phys . 2005;63:1592–1603
  18. Buchai A , Koswig S , Dinges S , et al.   Impact of the filling status of the bladder and rectum on their integral dose distribution and the movement of the uterus in the treatment planning of gynecological cancer . Radiother Oncol . 1999;52:29–34
  19. Wang JZ , Li XA , D’Souza W , et al.   Impacts of prolonged dose-delivery time on tumor control (A note of caution for IMRT) . Int J Radiat Oncol Biol Phys . 2003;57:543–552
  20. Shibamoto Y , Ito M , Sugie C , et al.   Recovery from sublethal damage during intermittent exposures in cultured tumor cells (Implications for dose modification in radiosurgery and IMRT) . Int J Rad Oncol Biol Phys . 2004;59:1484–1490
  21. Mutic S , Malyapa RS , Grigsby PW , et al.   PET-guided IMRT for cervical carinoma with positive para-aortice lymph nodes—A dose-escalation treatment planning study . Int J Radiat Oncol Biol Phys . 2003;55:28–35
  22. Molineu A , Alvarez P , Hernandez N , et al.   Analysis of Errors made during 163 IMRT irradiations of an anthropomorhic phantom . Int J Radiat Oncol Biol Phys . 2005;63:S58
  23. Brixey CS , Roeske JC , Lujan AE , et al.   Impact of intensity-modulated radiation therapy on acute hematologic toxicity in women with gynecologic malignancies . Int J Radiat Oncol Biol Phys . 2002;54:1388–1393
  24. Jordan TJ , Williams PC . The design and performance characteristics of a multileaf collimator . Phys Med Biol . 1994;39:231–251
  25. Arnfield MR , Siebers JV , Kim JO , et al.   A method for determining multileaf collimator transmission and scatter for dynamic intensity modulated radiotherapy . Med Phys . 2000;27:2231–2241
  26. Cadman P , Bassalow R , Sidhu NPS , et al.   Dosimetric considerations for validation of a sequential IMRT process with a commercial treatment planning system . Phys Med Biol . 2002;47:3001–3010
  27. Klein EE , Esthappan J , Li Z . Head scatter and surface/buildup dose characteristics for 6, 10, and 18 MV photons from an Elekta Precise accelerator . J Appl Clin Med Phys . 2003;4:1–7
  28. Sakthi N , Siebers J , Keall P , et al.   Monte-Carlo-based dosimetry of H&N patients treated with SIB-IMRT . Int J Radiat Oncol Biol Phys . 2003;57:S209
  29. Sanchez-Dobladoa F , Capotec R , Rosello J , et al.   Micro ionization chamber dosimetry in IMRT verification (Clinical implications of dosimetric errors in the PTV) . Radiother Oncol . 2005;75:342–348
  30. Mohan R , Wang X , Jackson A , et al.   The potential and limitations of the inverse radiotherapy technique . Radioth Oncol . 1994;32:232–248
  31. Bayouth J , Followill D , Nelson A , et al.   Dosimetric effect of a hip prosthesis when delivering intensity modulated radiation therapy (IMRT) (A phantom study) . Radiother Oncol . 2003;68:S105
  32. Followill DS , Stovall M , Kry SF , et al.   Neutron source strength measurements for Varian, Siemens, Elekta and General Electric linear accelerators . J. Applied Clin Med Phys . 2003;4:189–194
  33. Followill D , Geis P , Boyer A . Estimates of whole-body dose equivalent produced by beam intensity modulated conformal therapy . Int J Radiat Oncol Biol Phys . 1997;38:667–672
  34. Followill D , Geis P , Boyer A . Errata (Estimates of wholebody dose equivalent produced by beam intensity modulated conformal therapy) . Int J Radiat Oncol Biol Phys . 1997;38:783
  35. Mutic S , Low DA . Whole-body dose from tomotherapy delivery . Int J Radiation Oncology Biol Phys . 1998;42:229–232
  36. Palta JR , Hogstrom KR , Tannanonta C . Neutron leakage measurements from a medical linear accelerator . Med Phys . 1984;11:498–501
  37. Mechalakos JG , St. Germain J , Burman CM . Results of a one year survey of output for linear accelerators using IMRT and non-IMRT techniques . J Appl Clin Med Phys . 2004;5:64–71
  38. Woo MK , Nico A . Impact of multileaf collimator leaf positioning accuracy on intensity modulation radiation therapy quality assurance ion chamber measurements . Med Phys . 2005;32:1440–1445

PII: S1053-4296(06)00003-8

doi: 10.1016/j.semradonc.2006.02.002

Seminars in Radiation Oncology
Volume 16, Issue 3 , Pages 138-143 , July 2006