Seminars in Radiation Oncology
Volume 16, Issue 2 , Pages 102-110 , April 2006

Molecular Correlates of Site-Specific Metastasis

  • Charlotte Y. Dai, MD, PhD

      Affiliations

    • Department of Radiation Oncology, UCSF Comprehensive Cancer Center, San Francisco, CA
    • ,
  • Christopher M. Haqq, MD, PhD

      Affiliations

    • Department of Urology and Prostate Cancer Program, UCSF Comprehensive Cancer Center, San Francisco, CA
    • Corresponding Author InformationAddress reprint requests to Charlotte Dai, MD, PhD, Department of Radiation Oncology, UCSF Comprehensive Cancer Center, San Francisco, CA 94143
    • ,
  • J. Edward Puzas, MD

      Affiliations

    • Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY

References 

  1. Paget S . The distribution of secondary growths in cancer of the breast. 1889 . Cancer Metastasis Rev . 1989;8:98–101
  2. Ewing J . Neoplastic Diseases. A Treatise on Tumors . Philadelphia, PA: Saunders; 1928;
  3. Chambers AF , Groom AC , MacDonald AC , et al.   Dissemination and growth of cancer cells in metastatic sites . Nat Rev Cancer . 2002;2:563–572
  4. Fidler IJ . The pathogenesis of cancer metastasis (The ‘seed and soil’ hypothesis revisited) . Nat Rev Cancer . 2003;3:453–458
  5. Kinsey DL . An experimental study of preferential metastasis . Cancer . 1960;13:674–676
  6. Campbell JJ , Butcher EC . Chemokines in tissue-specific and microenvironment-specific lymphocyte homing . Curr Opin Immunol . 2000;12:336–341
  7. Zlotnik A , Yoshie O . Chemokines (A new classification system and their role in immunity) . Immunity . 2000;12:121–127
  8. Muller A , Homey B , Soto H , et al.   Involvement of chemokine receptors in breast cancer metastasis . Nature . 2001;410:50–56
  9. Taichman RS , Cooper C , Keller ET , et al.   Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone . Cancer Res . 2002;62:1832–1837
  10. Sun YX , Schneider A , Jung Y , et al.   Skeletal localization and neutralization of the SDF-1/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo . J Bone Miner Res . 2005;20:318–329
  11. Aiuti A , Cipponi A , Tavian M , et al.   Expression of CXCR4, the receptor for stromal cell derived factor 1 on fetal and adult human lympho-hematopoietic progenitors . Eur J Immunol . 1999;29:1823–1831
  12. Hirota S , Nagasawa T , Tachibana K , et al.   Defects of B-cell lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1 . Nature . 1996;382:635–638
  13. Magid M , Peled A , Ponomaryov T , et al.   Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4 . Science . 1999;283:845–848
  14. Nagasawa T , Nakajima T , Tachibana K , et al.   Molecular cloning and characterization of a murine pre-B-cell growth stimulating factor/stromal cell derived factor 1 receptor, a murine homolog of the human immunodeficiencey virus 1 entry coreceptor fusin . Proc Nat Acad Sci U S A . 1996;93:14726–14729
  15. Yin JJ , Selander K , Chirgwin JM , et al.   TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development . J Clin Invest . 1999;103:197–206
  16. Yoneda T , Williams PJ , Hiraga T , et al.   A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro . J Bone Miner Res . 2001;16:1486–1495
  17. Gordon AH , O’Keefe RJ , Schwarz EM , et al.   Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone . Cancer Res . 2005;65:3209–3217
  18. Coughlin SR . How the protease thrombin talks to cells . Proc Natl Acad Sci U S A . 1999;96:11023–11027
  19. Kay R , Kirk H , Whitehead I . Expression cloning of oncogenes by retroviral transfer of cDNA libraries . Mol Cell Biol . 1995;15:704–710
  20. Agarwal A , Boire A , Covic L , et al.   PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells . Cell . 2005;120:303–313
  21. Logothetis CJ , Lin SH . Osteoblasts in prostate cancer metastasis to bone . Nat Rev Cancer . 2005;5:21–28
  22. Nelson JB , Hedican SP , George DJ , et al.   Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate . Nat Med . 1995;1:944–949
  23. Carducci MA , Padley RJ , Bruel J , et al.   Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer (A randomized, phase II, placebo-controlled trial) . J Clin Oncol . 2003;21:679–689
  24. Nair KS , Naidoo R , Chetty R . Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value . J Clin Pathol . 2005;58:343–351
  25. Ponta H , Sherman L , Herrlich PA . CD44 (From adhesion molecules to signalling regulators) . Nat Rev Mol Cell Biol . 2003;4:33–45
  26. Wang Y , Klijn JG , Zhang Y , et al.   Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer . Lancet . 2005;365:671–679
  27. Stamenkovic I . Extracellular matrix remodelling (The role of matrix metalloproteinases) . J Pathol . 2003;200:448–464
  28. Yoshida BA , Sokoloff MM , Welch DR , et al.   Metastasis-suppressor genes (A review and perspective on an emerging field) . J Natl Cancer Inst . 2000;92:1717–1730
  29. Kang Y , Siegel PM , Shu W , et al.   A multigenic program mediating breast cancer metastasis to bone . Cancer Cell . 2003;3:537–549
  30. Giordano FJ , Ping P , McKirnan MD , et al.   Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart . Nat Med . 1996;2:534–539
  31. Moussad EE , Brigstock DR . Connective tissue growth factor (What’s in a name?) . Mol Genet Metab . 2000;71:276–292
  32. Manolagas SC . Role of cytokines in bone resorption . Bone . 1995;17(suppl 2):63S–67S
  33. Holliday LS , Welgus HG , Fliszar CJ , et al.   Initiation of osteoclast bone resorption by interstitial collagenase . J Biol Chem . 1997;272:22053–22058
  34. Zhao W , Byrne MH , Boyce BF , et al.   Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice . J Clin Invest . 1999;103:517–524
  35. Egeblad M , Werb Z . New functions for the matrix metalloproteinases in cancer progression . Nat Rev Cancer . 2002;2:161–174
  36. Kuno K , Terashima Y , Matsushima K , et al.   ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix . J Biol Chem . 1999;274:18821–18826
  37. Timar J , Lapis K , Dudas J , et al.   Proteoglycans and tumor progression (Janus-faced olecules with contradictory functions in cancer) . Semin Cancer Biol . 2002;12:173–186
  38. DeWinter JP , De Vries CJ , VanAchterberg TA , et al.   Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors . Exp Cell Res . 1996;224:323–334
  39. Lin SY , Morrison JR , Phillips DJ , et al.   Regulation of ovarian function by the TGF-beta superfamily and follistatin . Reproduction . 2003;126:133–148
  40. Minn AJ , Kang Y , Serganova I , et al.   Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors . J Clin Invest . 2005;115:44–55
  41. Minn AJ , Gupta GP , Siegel PM , et al.   Genes that mediate breast cancer metastasis to lung . Nature . 2005;436:518–524
  42. Duffy MJ , Maguire TM , Hill A , et al.   Metalloproteinases (Role in breast carcinogenesis, invasion and metastasis) . Breast Cancer Res . 2000;2:252–257
  43. Framson PE , Sage EH . SPARC and tumor growth (where the seed meets the soil?) . J Cell Biochem . 2004;92:679–690
  44. O’Hanlon DM , Fitzsimons H , Lynch J , et al.   Soluble adhesion molecules (E-selectin, ICAM-1 and VCAM-1) in breast carcinoma . Eur J Cancer . 2002;38:2252–2257
  45. Wood N , Whitters MJ , Jacobson BA , et al.   Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2 . J Exp Med . 2003;197:703–709
  46. Shelly M , Pinkas-Kramarski R , Guarino BC , et al.   Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes . J Biol Chem . 1998;273:10496–10505
  47. Yarden Y , Sliwkowski MX . Untangling the ErbB signalling network . Nat Rev Mol Cell Biol . 2001;2:127–137
  48. Ruzinova MB , Benezra R . Id proteins in development, cell cycle and cancer . Trends Cell Biol . 2003;13:410–418
  49. Fidler IJ , Kripke ML . Metastasis results from preexisting variant cells within a malignant tumor . Science . 1977;197:893–895
  50. Poste G , Fidler IJ . The pathogenesis of cancer metastasis . Nature . 1980;283:139–146
  51. van’t Veer LJ , Dai H , van de Vijver MJ , et al.   Gene expression profiling predicts clinical outcome of breast cancer . Nature . 2002;415:530–536
  52. Weigelt B , Glas AM , Wessels LF , et al.   Gene expression profiles of primary breast tumors maintained in distant metastases . Proc Natl Acad Sci U S A . 2003;100:15901–15905
  53. Messing EM , Manola J , Sarosdy M , et al.   Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer . N Engl J Med . 1999;341:1781–1788
  54. Partin AW , Yoo J , Carter HB , et al.   The use of prostate specific antigen, clinical stage and Gleason score to predict pathological stage in men with localized prostate cancer . J Urol . 1993;150:110–114
  55. Roach M , DeSilvio M , Lawton C , et al.   Phase III trial comparing whole-pelvic versus prostate-only radiotherapy and neoadjuvant versus adjuvant combined androgen suppression (Radiation Therapy Oncology Group 9413) . J Clin Oncol . 2003;21:1904–1911
  56. Roach M , Marquez C , Yuo HS , et al.   Predicting the risk of lymph node involvement using the pre-treatment prostate specific antigen and Gleason score in men with clinically localized prostate cancer . Int J Radiat Oncol Biol Phys . 1994;28:33–37
  57. Chu JH , Sun ZY , Meng XL , et al.   Differential metastasis-associated gene analysis of prostate carcinoma cells derived from primary tumor and spontaneous lymphatic metastasis in nude mice with orthotopic implantation of PC-3M cells . Cancer Lett . 2006;233:79–88
  58. Nomura T , Katunuma N . Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells . J Med Invest . 2005;52:1–9
  59. Hood JD , Cheresh DA . Role of integrins in cell invasion and migration . Nat Rev Cancer . 2002;2:91–100
  60. Trojanowska M . Ets factors and regulation of the extracellular matrix . Oncogene . 2000;19:6464–6471
  61. Chorostowska-Wynimko J , Skrzypczak-Jankun E , Jankun J . Plasminogen activator inhibitor type-1 (Its structure, biological activity and role in tumorigenesis) . Int J Mol Med . 2004;13:759–766
  62. Duffy MJ . The urokinase plasminogen activator system (Role in malignancy) . Curr Pharm Des . 2004;10:39–49
  63. Woelfle U , Cloos J , Sauter G , et al.   Molecular signature associated with bone marrow micrometastasis in human breast cancer . Cancer Res . 2003;63:5679–5684
  64. Kikuchi T , Daigo Y , Katagiri T , et al.   Expression profiles of non-small cell lung cancers on cDNA microarrays (Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs) . Oncogene . 2003;22:2192–2205
  65. Paik S , Shak S , Tang G , et al.   A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer . N Engl J Med . 2004;351:2817–2826
  66. Bartel DP . MicroRNAs (Genomics, biogenesis, mechanism, and function) . Cell . 2004;116:281–297
  67. Ambros V . MicroRNA pathways in flies and worms (growth, death, fat, stress, and timing) . Cell . 2003;113:673–676
  68. McManus MT . MicroRNAs and cancer . Semin Cancer Biol . 2003;13:253–258
  69. Pasquinelli AE , Reinhart BJ , Slack F , et al.   Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA . Nature . 2000;408:86–89
  70. Reinhart BJ , Slack FJ , Basson M , et al.   The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans . Nature . 2000;403:901–906
  71. Takamizawa J , Konishi H , Yanagisawa K , et al.   Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival . Cancer Res . 2004;64:3753–3756
  72. Calin GA , Sevignani C , Dumitru CD , et al.   Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers . Proc Natl Acad Sci U S A . 2004;101:2999–3004
  73. Karube Y , Tanaka H , Osada H , et al.   Reduced expression of Dicer associated with poor prognosis in lung cancer patients . Cancer Sci . 2005;96:111–115
  74. Michael MZ , O’Conner SM , van Holst Pellekaan NG , et al.   Reduced accumulation of specific microRNAs in colorectal neoplasia . Mol Cancer Res . 2003;1:882–891
  75. Calin GA , Dumitru CD , Shimizu M , et al.   Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia . Proc Natl Acad Sci U S A . 2002;99:15524–15529
  76. Ota A , Tagawa H , Karnan S , et al.   Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma . Cancer Res . 2004;64:3087–3095
  77. He L , Thomson JM , Hemann MT , et al.   A microRNA polycistron as a potential human oncogene . Nature . 2005;435:828–833
  78. Lu J , Getz G , Miska EA , et al.   MicroRNA expression profiles classify human cancers . Nature . 2005;435:834–838
  79. Chen G , Gharib TG , Huang CC , et al.   Discordant protein and mRNA expression in lung adenocarcinomas . Mol Cell Proteomics . 2002;1:304–313
  80. Cai Z , Chiu JF , He QY , et al.   Application of proteomics in the study of tumor metastasis . Genomics Proteomics Bioinformatics . 2004;2:152–166
  81. Meyerson M , Carbone D . Genomic and proteomic profiling of lung cancers (Lung cancer classification in the age of targeted therapy) . J Clin Oncol . 2005;23:3219–3226
  82. Liotta LA , Espina V , Woodhouse EC , et al.   Protein microarrays (Meeting analytical challenges for clinical applications) . Cancer Cell . 2003;3:317–325
  83. Paweletz CP , Charboneau L , Bichsel VE , et al.   Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front . Oncogene . 2001;20:1981–1989
  84. Wulfkuhle JD , Aquino JA , Calvert VS , et al.   Signal pathway profiling of ovarian cancer from human tissue specimens using reverse-phase protein microarrays . Proteomics . 2003;3:2085–2090
  85. Khor LY , Desilvio M , Al-Saleem T , et al.  Radiation Therapy Oncology Group   MDM2 as a predictor of prostate carcinoma outcome (An analysis of Radiation Therapy Oncology Group Protocol 8610) . Cancer . 2005;104:962–967
  86. Johnson SM , Grosshans H , Shingara J , et al.   RAS is regulated by the let-7 microRNA family . Cell . 2005;120:635–647

PII: S1053-4296(05)00100-1

doi: 10.1016/j.semradonc.2005.12.005

Seminars in Radiation Oncology
Volume 16, Issue 2 , Pages 102-110 , April 2006

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