« Previous
Next »
Seminars in Radiation Oncology
Volume 16, Issue 1
, Pages 51-58
, January 2006
Radiation and New Molecular Agents Part I: Targeting ATM-ATR Checkpoints, DNA Repair, and the Proteasome
References
-
.
Basis of cell kill following clinical radiotherapy, in Sluyser, Mels (eds)
(Application of Apoptosis to Cancer Treatment)
. Dordrecht, The Netherlands: Springer Publishing; 2005;
-
.
Genetic instability and DNA repair
.
In:
Tannock IFHR
, Harrington L
, Bristow RG
editor.
The Basic Science of Oncology
. 4th ed.. New York: McGraw-Hill Ltd; 2005;p. 77–99
- Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts . Nucleic Acids Res . 2005;33:2531–2539
- Selective targeting of homologous DNA recombination repair by gemcitabine . Int J Radiat Oncol Biol Phys . 2003;57:553–562
- . Mammalian cell cycle checkpoints (signalling pathways and their organization in space and time) . DNA Repair (Amst) . 2004;3:997–1007
- . Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage . Nat Genet . 2005;37:193–197
- . The p53 protein family and radiation sensitivity (Yes or no?) . Cancer Metastasis Rev . 2004;23:237–257
- . Radiation and the cell cycle, revisited . Cancer Metastasis Rev . 2004;23:209–225
- Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo . Oncogene . 2004;23:3328–3337
- . Cell cycle checkpoints and their impact on anticancer therapeutic strategies . J Cell Biochem . 2004;91:223–231
- Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors . Cancer Res . 2003;63:1550–1554
- Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM . Cancer Res . 2004;64:9152–9159
- Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy . Clin Cancer Res . 2003;9:93–101
- . Clinical trials (The sensitizing side of Onyx-015) . Gene Ther . 2005;12:386–387
- A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy . Science . 1999;285:1733–1737
- . G2 checkpoint abrogators as anticancer drugs . Mol Cancer Ther . 2004;3:513–519
- . Protein kinase inhibitors (Insights into drug design from structure) . Science . 2004;303:1800–1805
- 7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines . Radiat Res . 2002;158:84–93
- Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage . Mol Cell Biol . 2005;25:3553–3562
- . RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells . Cancer Res . 2005;65:2872–2881
- . The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma . Int J Radiat Oncol Biol Phys . 1997;39:1153–1161
- DNA damage-related RNA expression to assess individual sensitivity to ionizing radiation . Carcinogenesis . 2001;22:1179–1183
- Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients . Br J Cancer . 2004;90:2356–2363
- Defective DNA strand break repair after DNA damage in prostate cancer cells (implications for genetic instability and prostate cancer progression) . Cancer Res . 2004;64:8526–8533
- Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy . J Biol Chem . 2004;279:2273–2280
- . Homologous recombination-mediated double-strand break repair . DNA Repair (Amst) . 2004;3:827–833
- Elevated levels of Rad51 recombination protein in tumor cells . Cancer Res . 2002;62:219–225
- Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy . Nature . 2005;434:917–921
- Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells . Nucleic Acids Res . 2001;29:1534–1538
- Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity . Cancer Res . 2003;63:7377–7383
-
BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance
.
Mol Cell
. 2001;8:795–806
- . DNA-binding properties of poly(ADP-ribose) polymerase (a target for anticancer therapy) . Curr Drug Targets . 2004;5:357–365
- Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase . Nature . 2005;434:913–917
- . The mechanism of non-homologous end-joining (A synopsis of synapsis) . DNA Repair . 2004;3:1425–1435
-
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci
.
Mol Cell
. 2004;16:715–724
- Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM . Cancer Res . 2005;65:1670–1677
- . Vanillins—A novel family of DNA-PK inhibitors . Nucleic Acids Res . 2003;31:5501–5512
-
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia
.
Blood
. 2004;103:
4659–4565
- Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1 . Cancer Res . 2003;63:6008–6115
- . Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines . Cancer Res . 2004;64:7144–7149
- The role of the ubiquitin/proteasome system in cellular responses to radiation . Oncogene . 2003;22:5755–5773
-
Proteasome involvement in the repair of DNA double-strand breaks
.
Mol Cell
. 2004;16:1027–1034
- . Protease inhibitors restore radiation-induced apoptosis to Bcl-2-expressing lymphoma cells . Int J Cancer . 2001;96:327–333
- The proteasome inhibitor PS-341 in cancer therapy . Clin Cancer Res . 1999;5:2638–2645
- The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells . Cancer Res . 2002;62:5230–5235
- DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis . Nature . 2005;434:864–870
- DNA double strand break quantification in skin biopsies . Radiother Oncol . 2004;72:311–317
- Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents . J Clin Oncol . 2003;21:2760–2776
Supported by operating grants from the Terry Fox Foundation, National Cancer Institute of Canada, Ontario Cancer Research Network, the Prostate Cancer Research Foundation of Canada, and the US Army DOD Prostate Cancer Research Program. RGB is a Canadian Cancer Society Research Scientist. The first two authors contributed equally to this manuscript.
PII: S1053-4296(05)00051-2
doi: 10.1016/j.semradonc.2005.08.007
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
Seminars in Radiation Oncology
Volume 16, Issue 1
, Pages 51-58
, January 2006
