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Seminars in Radiation Oncology
Volume 13, Issue 1
, Pages 62-72
, January 2003
Chemical radioprotection: A critical review of amifostine as a cytoprotector in radiotherapy
References
- . Altered fractionation trials in head and neck cancer. Semin Radiat Oncol. 1998;8:230–236
- . Early Reactions as Dose-Limiting Factors in Radiotherapy. Semin Radiat Oncol. 1994;4:55–67
- . Conformal radiotherapy and intensity-modulated radiotherapy—Clinical data. Acta Oncol. 2000;39:555–567
- . Protection of salivary function by intensity-modulated radiation therapy in patients with head and neck cancer. Semin Radiat Oncol. 2002;12:20–25
- . Radioprotection by antioxidants. Ann N Y Acad Sci. 2000;899:44–60
-
.
Ethyol® (amifostine) for Injection.
1999;
- . Randomized phase III study of chemoradiation with or without amifostine for patients with favorable performance status inoperable stage II-III non-small cell lung cancer: Preliminary results. Semin Radiat Oncol. 2002;12:46–49
- . Jr: Esophageal cancer and the esophagus: challenges and potential strategies for selective cytoprotection of the tumor-bearing organ during cancer treatment. Semin Radiat Oncol. 2002;12:62–67
- . Exploring the role of the radioprotector amifostine in locally advanced non-small cell lung cancer: Radiation Therapy Oncology Group trial 98-01. Semin Radiat Oncol. 2002;12:40–45
- . Phase II: Trial of twice weekly amifostine in patients with non-small cell lung cancer treated with chemoradiotherapy. Semin Radiat Oncol. 2002;12:34–39
- . A prospective, nonrandomized study of the impact of amifostine on subsequent hypothyroidism in irradiated patients with head and neck cancers. Semin Radiat Oncol. 2002;12:14–17
- . The potential role of amifostine in the treatment of carcinoma of the uterine cervix: A review. Semin Radiat Oncol. 2002;12:68–74
- . Toxicity antagonists in head and neck cancer. Semin Radiat Oncol. 1998;8:282–291
-
.
Cysteine protection against X irradiation.
Science. 1949;110:213–214
-
.
Radioprotectors Radiobiology for the radiologist.
In: Philadelphia, PA: Lippincott; 2000;p. 136–146
- . Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2(3-aminopropylamino)-ethylphosphorothioic acid. Cancer Res. 1980;40:1519–1524
- . Protective drugs in cancertherapy: optimal clinical testing and future directions. Int J Radiat Oncol Biol Phys. 1982;8:513–517
- . American Society of Clinical Oncology clinical practice guidelines for the use of chemotherapy and radiotherapy protectants. J Clin Oncol. 1999;17:3333–3355
-
.
Pharmacokinetic profile of amifostine.
Sem Oncol. 1999;23:18–22
- . Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721. Int J Radiat Oncol Biol Phys. 1984;10:1525–1528
- . Prediction of the effective radioprotective dose of WR-2721 in humans through an interspecies tissue distribution study. Radiat Res. 1976;66:100–105
- . The modification of melphalan toxicity in tumor bearing mice by s-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR 2721). Am J Clin Oncol. 1982;5:321–328
- . Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage. Int J Radiat Biol. 1997;71:193–202
-
.
Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (WR-2721): Preclinical aspects.
Eur J Cancer. 1995;31A(suppl 1):S1–S7
- . The oxygen dependence of protection by aminothiols: Implications for normal tissues and solid tumors. Int J Radiat Oncol Biol Phys. 1984;10:1495–1501
- . Radioprotection of mouse skin by WR-2721: the critical influence of oxygen tension. Int J Radiat Oncol Biol Phys. 1982;8:531–534
- . Radiosensitization and radioprotection by BSO and WR-2721: The role of oxygenation. Br J Cancer. 1989;60:517–522
- . Radioprotection by WR-2721 in vitro at low oxygen tensions: Implications for its mechanisms of action. Br J Cancer. 1983;47:387–392
-
.
The effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR2721) on intestinal crypt survival. II. Fission neutrons.
Radiat Res. 1976;95:430–439
- . Radioprotection of normal tissues against gamma rays and cyclotron neutrons with WR-2721: LD50 studies and 35S-WR-2721 biodistribution. Radiat Res. 1984;97:598–607
- . Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N"-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278). Mutagenesis. 1994;9:355–360
- . Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression. Pharmacol Ther. 1988;39:133–137
- . Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065. Cancer Res. 1995;55:4788–4792
- . The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation. Carcinogenesis. 1992;13:811–814
- . Radioprotection of salivary glands by S-2-(3-aminopropylamin)-ethylphosphorothioic (amifostine) obtained in a rabbit animal model. Int J Radiat Oncol Biol Phys. 1999;45:181–186
- . Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. J Clin Invest. 1991;87:694–703
- . Fractionated studies with WR-2721: Normal tissues and tumour. Radiother Oncol. 1986;6:51–60
- . Variation in normal tissue responsiveness to WR-2721. Int J Radiat Oncol Biol Phys. 1984;10:1537–1539
- . Dephosporylation of WR-2721 with mouse tissue homogenates. Int J Radiat Oncol Biol Phys. 1984;10:1529–1531
- . The influence of X ray dose level on normal tissue radioprotection by WR-2721. Int J Radiat Oncol Biol Phys. 1984;10:2351–2356
- . Alkaline phosphatase promotes radioprotection and accumulation of WR- 1065 in V79-171 cells incubated in medium containing WR-2721. Int J Radiat Biol Relat Stud Phys Chem Med. 1985;47:23–27
- . Effect of the chemoprotective agent WR-2721 on disposition and biotransformations of ormaplatin in the fischer 344 rat bearing a fibrosarcoma. Cancer Res. 1995;55:2837–2846
- . Clinical trials of WR-2721 with radiation therapy. Int J Radiat Oncol Biol Phys. 1982;8:561–563
- . A randomised study of very accelerated radiotherapy with and without amifostine in advanced head and neck squmaous cell carcinoma. Int J Radiat Oncol Biol Phys. 2000;46:1105–1108
- . New dosing regimens for amifostine: a pilot study to compare the relative bioavailability of oral and subcutaneous administration with intravenous infusion. J Clin Pharmacol. 2002;42:166–174
- . Subcutaneous administration of amifostine during fractionated radiotherapy: a randomized phase II study. J Clin Oncol. 2000;18:2226–2233
- . Jr: A phase II trial of subcutaneous amifostine and radiation therapy in patients with head and neck cancer. Semin Radiat Oncol. 2002;12:18–19
- . The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects. Br J Cancer. 1999;80:629–638
- . Amifostine: the preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies. Semin Oncol. 1996;23(suppl 8):2–17
- . Radioprotective effects of amifostine. Semin Oncol. 1999;26(suppl 7):89–94
- . Experimental radiotherapy with WR-2721 and misonidazole. Int J Radiat Oncol Biol Phys. 1982;8:527–530
- . Influence of WR 2721 on the efficiacy of radiotherapy and chemotherapy in murine tumors. Int J Radiat Oncol Biol Phys. 1982;8:539–542
- . Effect of radioprotective drugs on the therapeutic ratio for a mouse tumor system. Acta Radiol Ther Phys Biol. 1973;12:425–433
- . Protective effects of S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice. Cancer Res. 1982;42:1888–1897
- . Effect of the radioprotective drugs MEA, DMSO, and WR-2721 on tumor control and skin tolerance in the rat. Cancer Treat Rep. 1977;61:825–833
- . Radioprotection of tumor and normal tissues by thiophosphate compounds. Cancer. 1973;32:528–535
-
.
Differential radioprotection of euoxic and hypoxic mouse mammary tumors by a thiophosphate compound.
Radiol. 1974;110:213–216
-
.
Radiotherapy of experimental lung tumors in the presence and absence of a radioprotective drug, S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721).
J Natl Cancer Ins. 1973;50:69–78
- . Combined use of radioprotective and radiosensitizing drugs in experimental radiotherapy. Radiat Res. 1977;70:433–443
- . Differential chemoprotection of normal and malignant tissues. J Natl Cancer Inst. 1969;42:331–335
- . Influence of WR 2721 on radiation response of canine soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 1986;12:1957–1963
- . Efficacy testing of WR-2721 in Great Britain everything is black and white at the Gray lab. Int J Radiat Oncol Biol Phys. 1983;9:595–598
- . Is the outlook grey for WR-2721 as a clinical radioprotector. Int J Radiat Oncol Biol Phys. 1983;9:1247–1249
- . Has the outlook improved for amifostine as a clinical radioprotector?. Radiother Oncol. 2000;57:113–118
- . Has the outlook improved for amifostine as a clinical radioprotector. Radiother Oncol. 2001;60:334–336
- . Modification by WR 2721 of the response to chemotherapy of tumours and normal tissues in the mouse. Br J Cancer. 1983;47:57–63
- . Tumor blood flow changes induced by chemical modifiers of radiation response. Int J Radiat Oncol Biol Phys. 1992;22:459–462
- . A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: an interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix. Radiother Oncol. 1993;26:93–103
- . Effect of tumor type, size and endpoint on tumor radioprotection by WR-2721. Int J Radiat Oncol Biol Phys. 1984;10:41–48
- . Interaction of misonidazole and WR-2721—II. Modification of tumour radiosensitization. Br J Cancer. 1983;47:65–72
- . Preliminary results of a pilot study using WR-2721 before fractionated irradiation of the head and neck to reduce salivary gland dysfunction. Int J Radiat Oncol Biol Phys. 1994;29:747–754
- . Salivary gland protection by amifostine in high-dose radioiodine treatment: results of a double-blind placebo-controlled study. J Clin Oncol. 1998;16:3542–3549
- . Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. J Clin Oncol. 2000;18:3339–3345
- . Effect of amifostine on patient assessed clinical benefit in irradiated head and neck cancer. Int J Radiat Oncol Biol Phys. 2000;48:1035–1039
- . Selective cytoprotection with amifostine in concurrent radiochemotherapy for head and neck cancer. Ann Oncol. 1998;9:505–509
- . Economic analysis of amifostine as adjunctive support for patients with advanced head and neck cancer: preliminary results from a randomized phase II clinical trial from Germany. Cancer Invest. 2001;19:107–113
-
.
Supportive use of amifostine in patients with head and neck tumors undergoing radio-chemotherapy. Is it possible to limit the duration of the application of amifostine?.
Strahlenther Onkol. 1999;175(suppl 4):23–26
- . Side effects of postoperative radiochemotherapy with amifostine versus radiochemotherapy alone in head and neck tumors. Preliminary results of a prospective randomized trial. Strahlenther Onkol. 1999;175(suppl 4):18–22
- . Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2002;52:739–747
- . Randomized phase III trial of radiation treatment +/− amifostine in patients with advanced-stage lung cancer. Int J Radiat Oncol Biol Phys. 2001;51:915–922
- . Clinical study of radioprotective effects of amifostine (YM-08310, WR-2721) on long-term outcome for patients with cervical cancer. Int J Radiat Oncol Biol Phys. 1993;26:407–411
- . Use of radiation with or without WR-2721 in advanced rectal cancer. Cancer. 1992;69:2820–2825
- . A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys. 1995;33:99–109
-
.
The role of cytokines in the development of normal-tissue reactions after radiotherapy.
Strahlenther Onkol. 1998;174(suppl 3):12–15
- . Normal tissue radiobiology: From the laboratory to the clinic. Int J Radiat Oncol Biol Phys. 2001;49:353–365
- . TGF-beta 1 and radiation fibrosis: A master switch and a specific therapeutic target?. Int J Radiat Oncol Biol Phys. 2000;47:277–290
- . Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: An experimental study. Int J Radiat Oncol Biol Phys. 1999;43:839–847
-
.
Pharmacological intervention to prevent or ameliorate chronic radiation injuries.
Semin Radiat Oncol. 2002;
- . Radiation apoptosis of serous acinar cells of salivary and lacrimal glands. Cancer. 1991;67:1539–1543
- . Design and interpretation of clinical trials that evaluate agents that may offer protection from the toxic effects of cancer chemotherapy. J Clin Oncol. 1998;16:3179–3190
- . The presence of wild-type TP53 is necessary for the radioprotective effect of the Bowman-Birk proteinase inhibitor in normal fibroblasts. Radiat Res. 1998;150:648–655
- . Modification of oral mucositis by keratinocyte growth factor: Single radiation exposure. Int J Radiat Biol. 2001;77:341–347
☆ Address reprint requests to Christian Nicolaj Andreassen, MD, Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebroggade 44, DK 8000 Aarhus C, Denmark.
PII: S1053-4296(03)50009-1
doi: 10.1053/srao.2003.50006
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Seminars in Radiation Oncology
Volume 13, Issue 1
, Pages 62-72
, January 2003
