Targeting the tumor blood vessel network to enhance the efficacy of radiation therapy

The effect of bFGF antisense treatment on the radiation response of Caki-1 xenografts. Mice were treated with two 10 mg/kg doses of bFGF antisense either alone or in combination with a 10-Gy dose of radiation delivered locally. Antisense bFGF was prepared in liposomes and administered in 2 increments, the first given immediately after irradiation and the second 3 days postradiotherapy.

Impact on KHT sarcoma tumor cell survival of administering a 17.5 mg/kg dose of DMXAA at various times before or after a 10-Gy dose of radiation. Data shown are the mean ± standard error of 3 to 6 experiments. The hatched area shows the survival range for radiation alone.

Tumor cell survival in KHT sarcomas treated with a 17.5 mg/kg dose of DMXAA 1 hour after a range of single doses of radiation. Tumors were evaluated 24 hours after completing the treatment. Results are the mean ± standard error of 3 to 6 experiments.

Tumor surviving fractions in KHT sarcomas of varying sizes treated with a single dose of either CA4DP or ZD6126 and assayed 24 hours later. Bars are the mean ± standard error of 3 to 6 tumors except those without errors that represent individual tumors. Tumor surviving fractions were determined by multiplying the calculated fraction of surviving cells by the ratio of cells recovered in treated versus untreated tumors.