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Seminars in Radiation Oncology
Volume 13, Issue 1
, Pages 31-41
, January 2003
Modulation of cell death in the tumor microenvironment
References
- Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol. 1953;26:638–648
- . Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A. 1988;85:9533–9537
- . Relationship of hypoxia to metastatic ability in rodent tumours. Br J Cancer. 2001;84:1280–1285
- Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 1996;379:88–91
- Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res. 1997;57:4200–4204
- . Hypoxia-induced metastasis of human melanoma cells: Involvement of vascular endothelial growth factor-mediated angiogenesis. Br J Cancer. 1999;80:1697–1707
- Response of tumour cells to hypoxia: Role of p53 and NFkB. Mol Pathol. 1998;51:55–61
- . Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol. 2000;35:71–103
- Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996;56:4509–4515
- Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 1997;38:285–289
- Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations. Br J Cancer. 2001;84:1070–1075
- . Regulation of hypoxia-induced angiogenesis: A chaperone escorts VEGF to the dance. J Clin Invest. 2001;108:39–40
- Oxygenation of head and neck tumors. Cancer. 1993;71:2319–2325
- Changes in the oxygenation of head and neck tumors during carbogen breathing. Radiother Oncol. 1993;27:123–130
- . Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol. 1996;41:31–39
- Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res. 1996;56:5522–5528
- In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med. 2001;7:864–868
- . Microenvironment-induced cancer metastasis. Int J Radiat Biol. 2000;76:589–605
- . Mutagenesis induced by the tumor microenvironment. Mutat Res. 1998;400:439–446
- . Biological consequences of tumor hypoxia. Semin Oncol. 2001;28:36–41
- Vascular endothelial growth factor is essential for corpus luteum angiogenesis. Nat Med. 1998;4:336–340
- . Endothelial proliferation in tumours and normal tissues: continuous labelling studies. Br J Cancer. 1984;49:405–413
- . Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol. 1999;15:551–578
- Candidate genes for the hypoxic tumor phenotype. Cancer Res. 2000;60:883–887
- HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 2001;61:6669–6673
- . Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci U S A. 2000;97:9082–9087
-
.
A matter of life and death.
Cancer Cell. 2002;1:19–30
- Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?. Oncogene. 1998;17:2333–2337
- Cancer cells surviving hypoxia obtain hypoxia resistance and maintain anti-apoptotic potential under reoxygenation. Int J Cancer. 2001;91:322–326
- . Effects of hypoxia on drug resistance phenotype and genotype in human glioma cell lines. J Neurooncol. 1996;29:149–155
- Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model. Int J Radiat Oncol Biol Phys. 2001;51:840–848
- Pretranslational regulation of two cardiac glucose transporters in rats exposed to hypobaric hypoxia. Am J Physiol. 1992;263:E562–E569
- Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3' enhancer. Proc Natl Acad Sci U S A. 1994;91:6496–6500
- Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem. 1994;269:23757–23763
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399:271–275
- Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001;292:468–472
- HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science. 2001;292:464–468
- A protective role for HIF-1 in response to redox manipulation and glucose deprivation: Implications for tumorigenesis. Oncogene. 2002;21:282–290
- Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol. 2001;21:3436–3444
- A protective role for HIF-1 in response to redox manipulation and glucose deprivation: Implications for tumorigenesis. Oncogene. 2002;21:282–290
- . Oncogenic alterations of metabolism. Trends Biochem Sci. 1999;24:68–72
- Cellular growth and metabolic adaptations to nutrient stress environments in tumor microregions. Int J Radiat Oncol Biol Phys. 1986;12:611–615
- . Oxygen effects in radiobiology. Adv Exp Med Biol. 1982;157:123–144
- Cellular growth and metabolic adaptations to nutrient stress environments in tumor microregions. Int J Radiat Oncol Biol Phys. 1986;12:611–615
- Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc Natl Acad Sci U S A. 1996;93:9493–9498
- . Regulation of protein metabolism of human cells during and after acute hypoxia. Cancer Res. 1986;46:4346–4351
- Adenine nucleotides and inhibition of protein synthesis in isolated hepatocytes incubated under different pO2 levels. Arch Biochem Biophys. 1993;304:322–331
-
.
Pathway and mechanism of initiation of protein synthesis.
In:
Sonenberg N, Hershey JW, Mathews MB editor.
Translational control of gene expression. Cold Spring Harbor: Cols Spring Harbor Laboratory Press; 2000;p. 33–88
- Regulation of protein synthesis by hypoxia via activation of the protein kinase PERK and phosphorylation of elF2alpha. Mol Cell Biol. 2002;22:7405–7416
-
Paper presented at the 93rd Annual Meeting of the American Association for Cancer Research, San Francsico, CA, Regulation of protein translation during hypoxic conditions. April 6-10, 2002;
- Hypoxia as a target for combined modality treatments. Eur J Cancer. 2002;38:240–257
- . Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers. Semin Radiat Oncol. 1996;6:10–21
-
.
Clinical results of hypoxic cell radiosensitisation from hyperbaric oxygen to accelerated radiotherapy, carbogen and nicotinamide.
Br J Cancer. 1996;27:S271–S278
(Suppl)
- . Sensitization of hypoxic tumour cells—Clinical experience. Int J Radiat Biol. 1989;56:801–811
- Prognostic value of pretreatment factors in patients with locally advanced carcinoma of the uterine cervix treated by radiotherapy alone. Acta Oncol. 1995;34:787–795
- Prognostic value of hemoglobin concentrations and blood transfusions in advanced carcinoma of the cervix treated by radiation therapy: Results of a retrospective study of 386 patients. Int J Radiat Oncol Biol Phys. 1989;16:37–42
- Pretreatment hemoglobin level influences local control and survival of T1-T2 squamous cell carcinomas of the glottic larynx. J Clin Oncol. 1995;13:2077–2083
- Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: A secondary analysis of RTOG 85-27. Int J Radiat Oncol Biol Phys. 1998;42:1069–1075
- The prognostic value of hemoglobin and a decrease in hemoglobin during radiotherapy in laryngeal carcinoma. Radiother Oncol. 1992;23:229–235
- T1/T2 glottic cancer managed by external beam radiotherapy: The influence of pretreatment hemoglobin on local control. Int J Radiat Oncol Biol Phys. 1998;41:347–353
- Anemia is associated with lower local-regional control and survival after radiation therapy for head and neck cancer: a prospective study. Radiology. 1996;201:553–558
- . Radiation myelitis and survival in the radiotherapy of lung cancer. Int J Radiat Oncol Biol Phys. 1988;15:75–81
- Results of treatment and lessons learned from pathologically staged T4 non-small cell lung cancer. J Surg Oncol. 1991;47:209–214
- The effect of arterial oxygen content on the results of radiation therapy for epidermoid bronchogenic carcinoma. Int J Radiat Oncol Biol Phys. 1989;16:1477–1481
- Local control of muscle-invasive bladder cancer: Preoperative radiotherapy and cystectomy versus cystectomy alone. Int J Radiat Oncol Biol Phys. 1995;32:331–340
- . Blood tests and prognosis in bladder carcinomas treated with definitive radiotherapy. Radiother Oncol. 1993;27:117–122
- . DNA analysis in predicting survival of irradiated patients with transitional cell carcinoma of bladder. Br J Urol. 1992;69:49–55
- . Prognostic factors in patients with bladder carcinoma treated with definitive irradiation. Cancer. 1990;65:908–912
- The influence of initial hemoglobin and blood pressure levels on results of radiation therapy for carcinoma of the prostate. Int J Radiat Oncol Biol Phys. 1989;16:1173–1178
- . Extrapolations from laboratory and preclinical studies for the use of carbogen and nicotinamide in radiotherapy. Radiother Oncol. 1992;24:123–124
- . Effect of nicotinamide on the microregional heterogeneity of oxygen delivery within a murine tumor. J Natl Cancer Inst. 1990;82:672–676
- . Radiosensitization with normobaric oxygen and carbogen. Radiother Oncol. 1991;1:65–70 (Suppl)
- Reducing acute and chronic hypoxia in tumours by combining nicotinamide with carbogen breathing. Acta Oncol. 1994;33:371–376
- Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients. Br J Cancer. 1995;72:198–205
- Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer. Radiother Oncol. 1998;48:115–122
- . Van der Kogel AJ: Clinical outcome and tumour microenvironmental effects of accelerated radiotherapy with carbogen and nicotinamide. Acta Oncol. 1999;38:875–882
- ARCON: Experience in 215 patients with advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2002;52:769–778
- . Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma: Hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen, and nicotinamide. Cancer. 1999;86:1322–1328
- ARCON: Accelerated radiotherapy with carbogen and nicotinamide in head and neck squamous cell carcinomas. The experience of the Co-operative group of radiotherapy of the european organization for research and treatment of cancer (EORTC). Radiother Oncol. 2000;55:111–1199
- . Therapeutic advantage of hypoxic cells in tumors: A theoretical study. J Natl Cancer Inst. 1991;83:178–185
- . Tirapazamine: a new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer. Ann Oncol. 1999;10:S29–S33
- . SR 4233 (tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours. Br J Cancer. 1993;67:1163–1170
- Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumors. Anaerobe. 1998;4:183–188
- . Tumor-targeted Salmonella as a novel anticancer vector. Cancer Res. 1997;57:4537–4544
- Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Ther. 1997;4:791–796
- Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum. Cancer Gene Ther. 2001;8:294–297
- . Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971;285:1182–1186
- Significance of angiogenesis in cancer therapy. Br J Surg. 1998;85:1044–1055
- . Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992;359:843–845
- Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol. 1995;15:5363–5368
- Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16:4604–4613
- . Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res. 1993;53:5822–5827
- SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 1999;59:99–106
- SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res. 2000;60:4152–4160
- PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000;60:2178–2189
- . Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics. J Clin Invest. 2000;106:1197–1202
- Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia. 2000;2:306–314
- . Angiostatin: An endogenous inhibitor of angiogenesis and of tumor growth. Exs. 1997;79:273–294
- Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997;88:277–285
- A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer. Clin Cancer Res. 2001;7:1888–1893
- . Angiogenesis and tumor metastasis. Annu Rev Med. 1998;49:407–424
- Urokinase receptor antagonists inhibit angiogenesis and primary tumor growth in syngeneic mice. Cancer Res. 1996;56:2428–2433
- Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice. Gene Ther. 1998;5:1105–1113
- . The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development. J Clin Invest. 1999;103:1227–1230
- Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med. 2002;8:27–34
- . Integrin indecision. Nat Med. 2002;8:14–16
- Effect of p53 status on tumor response to antiangiogenic therapy. Science. 2002;295:1526–1528
- Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches. Cancer Metastasis Rev. 2001;20:79–86
- Heterogeneous vascular dependence of tumor cell populations. Am J Pathol. 2001;158:1325–1334
- Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 2000;14:391–396
- Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics. Cancer Res. 2000;60:1541–1545
- Antisense inhibition of ras p21 expression that is sensitive to a point mutation. Biochemistry. 1991;30:8283–8286
- Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme. Cancer Res. 1995;55:2024–2028
- . Intracellular antibodies: Development and therapeutic potential. Trends Biotechnol. 1995;13:306–310
- Tumour biology: Herceptin acts as an anti-angiogenic cocktail. Nature. 2002;416:279–280
- . Epidermal growth factor receptors as a target for cancer treatment: The emerging role of IMC-C225 in the treatment of lung and head and neck cancers. Semin Oncol. 2002;29:27–36
- In vivo gene therapy with p53 or p21 adenovirus for prostate cancer. Cancer Res. 1995;55:5151–5155
- Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med. 1996;2:985–991
- . Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase. Nat Med. 2001;7:228–234
- Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists. Proc Natl Acad Sci U S A. 1999;96:4325–4329
☆ Address reprint requests to Bradly G. Wouters, PhD, Department of Experimental Radiation Oncology, UNS 50/Box 23, azM/University of Maastricht, Postbox 616, 6200 MD Maastricht, The Netherlands.
PII: S1053-4296(03)50006-6
doi: 10.1053/srao.2003.50004
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Seminars in Radiation Oncology
Volume 13, Issue 1
, Pages 31-41
, January 2003
